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    AAC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855078, updated on 11-Sep-2024

    Summary

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    Official Symbol
    AAC1
    Primary source
    SGD:S000004660
    Locus tag
    YMR056C
    See related
    AllianceGenome:SGD:S000004660; FungiDB:YMR056C; VEuPathDB:YMR056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP:ADP antiporter activity. Involved in several processes, including aerobic respiration; heme biosynthetic process; and heme transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to several human genes including SLC25A4 (solute carrier family 25 member 4) and SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (387315..388244, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V0 sector ATPase subunit a Neighboring gene Bub2p Neighboring gene ferroxidase FET3 Neighboring gene Sen15p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The delivery of ADP/ATP carrier protein to mitochondria probed by fusions with green fluorescent protein and beta-galactosidase. Polcicová K, et al. FEMS Yeast Res, 2003 Dec. PMID 14654436
    2. A Klaac null mutant of Kluyveromyces lactis is complemented by a single copy of the Saccharomyces cerevisiae AAC1 gene. Viola AM, et al. Curr Genet, 1999 Aug. PMID 10447592
    3. Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier. Iwahashi A, et al. Mitochondrion, 2008 Mar. PMID 18313366
    4. Difference between yeast and bovine mitochondrial ADP/ATP carriers in terms of conformational properties of the first matrix loop as deduced by use of copper-o-phenanthroline. Kihira Y, et al. Biol Pharm Bull, 2007 May. PMID 17473430
    5. A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Vergnolle MA, et al. Biochem J, 2005 Jan 1. PMID 15320873, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. all Cys residues that replaced 9 continuous amino acids in Met310-Lys318 showed high reactivity with eosin 5-maleimde regardless of presence of carboxyatractyloside or bongkrekate; this region was concluded to be exposed to water-accessible environment.
      Title: Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier.
    2. AAC contains a cryptic matrix targeting signal that can target up to two thirds of the N-terminal part of the protein to the matrix, and this event is coordinated by the TIM23 translocase
      Title: A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP/ATP carrier protein AAC1
    NP_013772.1
    • Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      387315..388244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182554.1 → NP_013772.1  TPA: ADP/ATP carrier protein AAC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZN1, P04710
      UniProtKB/TrEMBL
      A6ZMB6, B3LLV0, B5VPI5, C7GL67, C8ZEQ9, G2WKA5
      Conserved Domains (1) summary
      PTZ00169
      Location:9 → 303
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04710.1

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