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    Lypla1 lysophospholipase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25514, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Lypla1provided by RGD
    Official Full Name
    lysophospholipase 1provided by RGD
    Primary source
    RGD:3025
    See related
    EnsemblRapid:ENSRNOG00000008320 AllianceGenome:RGD:3025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    25KDL; APT-1; LPL-I; Pla1a; lysoPLA
    Summary
    Enables lysophospholipase activity. Predicted to be involved in fatty acid transport; negative regulation of aggrephagy; and protein depalmitoylation. Predicted to act upstream of or within negative regulation of Golgi to plasma membrane protein transport. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrion; and nucleus. Predicted to be active in cytoplasm. Orthologous to human LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 694.6), Liver (RPKM 510.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lypla1 in Genome Data Viewer
    Location:
    5q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (19477408..19506568, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (14679605..14708774, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (14559333..14588447, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 36 Neighboring gene regulator of G-protein signaling 20 Neighboring gene transcription elongation factor A1 Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene uncharacterized LOC102552817 Neighboring gene uncharacterized LOC120102814

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification, cDNA cloning, and regulation of lysophospholipase from rat liver. Sugimoto H, et al. J Biol Chem, 1996 Mar 29. PMID 8631810
    2. A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). Duncan JA, et al. J Biol Chem, 1998 Jun 19. PMID 9624183
    3. Phospholipase and lysophospholipase activity of rat eosinophil leukocytes. Ottolenghi A, et al. Arch Biochem Biophys, 2002 Oct 15. PMID 12361707
    4. Small-molecule inhibition of APT1 affects Ras localization and signaling. Dekker FJ, et al. Nat Chem Biol, 2010 Jun. PMID 20418879
    5. Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach. Shanado Y, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555596

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results reveal that LysoPLA I catalyzes the removal of n-octanoic acid from ghrelin to form des-acyl ghrelin
      Title: Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach.
    2. activity in eosinophil leukocytes
      Title: Phospholipase and lysophospholipase activity of rat eosinophil leukocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of aggrephagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acyl-protein thioesterase 1
    Names
    lysoPLA I
    lysophospholipase I
    palmitoyl-protein hydrolase
    NP_037138.1
    XP_038965233.1
    XP_038965234.1
    XP_038965236.1
    XP_063143256.1
    XP_063143257.1
    XP_063143258.1
    XP_063143259.1
    XP_063143260.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429408.1 → NP_001416337.1  acyl-protein thioesterase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NM_001429409.1 → NP_001416338.1  acyl-protein thioesterase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NM_001429410.1 → NP_001416339.1  acyl-protein thioesterase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5YBB3

    4. NM_001429411.1 → NP_001416340.1  acyl-protein thioesterase 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    5. NM_001429412.1 → NP_001416341.1  acyl-protein thioesterase 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    6. NM_013006.3 → NP_037138.1  acyl-protein thioesterase 1 isoform 2

      See identical proteins and their annotated locations for NP_037138.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P70470
      UniProtKB/TrEMBL
      A0A8I5ZTV1, A6JFJ3
      Related
      ENSRNOP00000011312.5, ENSRNOT00000011312.5
      Conserved Domains (1) summary
      pfam02230
      Location:8 → 226
      Abhydrolase_2; Phospholipase/Carboxylesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      19477408..19506568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287189.1 → XP_063143259.1  acyl-protein thioesterase 1 isoform X6

    2. XM_063287188.1 → XP_063143258.1  acyl-protein thioesterase 1 isoform X5

    3. XM_039109305.2 → XP_038965233.1  acyl-protein thioesterase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTV1, A0A8I6APY4
      Conserved Domains (1) summary
      pfam02230
      Location:8 → 229
      Abhydrolase_2; Phospholipase/Carboxylesterase

    4. XM_063287190.1 → XP_063143260.1  acyl-protein thioesterase 1 isoform X7

    5. XM_063287187.1 → XP_063143257.1  acyl-protein thioesterase 1 isoform X4

    6. XM_039109306.2 → XP_038965234.1  acyl-protein thioesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZTV1
      Related
      ENSRNOP00000083839.2, ENSRNOT00000117962.2
      Conserved Domains (1) summary
      pfam02230
      Location:8 → 213
      Abhydrolase_2; Phospholipase/Carboxylesterase

    7. XM_063287186.1 → XP_063143256.1  acyl-protein thioesterase 1 isoform X1

    8. XM_039109308.2 → XP_038965236.1  acyl-protein thioesterase 1 isoform X8

      Conserved Domains (1) summary
      cl21494
      Location:8 → 123
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70470.1 GenPept UniProtKB/Swiss-Prot:P70470

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