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    Myh11 myosin heavy chain 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24582, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Myh11provided by RGD
    Official Full Name
    myosin heavy chain 11provided by RGD
    Primary source
    RGD:3136
    See related
    EnsemblRapid:ENSRNOG00000057880 AllianceGenome:RGD:3136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytoskeletal motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in cardiac muscle cell development and elastic fiber assembly. Predicted to act upstream of or within smooth muscle contraction. Predicted to be located in brush border; smooth muscle contractile fiber; and stress fiber. Predicted to be part of muscle myosin complex. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 2994.9), Lung (RPKM 429.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myh11 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (1250554..1345681)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (743364..838459)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (764421..859184)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 1 Neighboring gene ribosomal protein S3a, pseudogene 8 Neighboring gene centrosomal protein 20 Neighboring gene nudE neurodevelopment protein 1 Neighboring gene microRNA 484

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myosin heavy chain isoform diversity in smooth muscle is produced by differential RNA processing. Babij P, et al. J Mol Biol, 1989 Dec 5. PMID 2614841
    2. Identification of a novel smooth muscle myosin heavy chain cDNA: isoform diversity in the S1 head region. White S, et al. Am J Physiol, 1993 May. PMID 7684561
    3. Smooth-muscle contraction without smooth-muscle myosin. Morano I, et al. Nat Cell Biol, 2000 Jun. PMID 10854329
    4. Molecular cloning and functional analysis of the promoter region of rat nonmuscle myosin heavy chain-B gene. Yam JW, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027611
    5. Loss of SM-B myosin affects muscle shortening velocity and maximal force development. Babu GJ, et al. Nat Cell Biol, 2001 Nov. PMID 11715025

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of muscle IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of muscle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in elastic fiber assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in elastic fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of muscle myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of muscle myosin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in smooth muscle contractile fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myosin-11
    Names
    SMMHC
    myosin heavy chain 21
    myosin, heavy chain 11, smooth muscle
    myosin, heavy polypeptide 11, smooth muscle
    smooth muscle myosin heavy chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170600.2 → NP_001164071.1  myosin-11 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A8G7
      Related
      ENSRNOP00000088033.1, ENSRNOT00000115537.2
      Conserved Domains (7) summary
      cd14921
      Location:99 → 771
      MYSc_Myh11; class II myosin heavy chain 11, motor domain
      pfam00063
      Location:87 → 771
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:848 → 1928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:34 → 71
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam16046
      Location:990 → 1082
      FAM76; FAM76 protein
      cl12013
      Location:1159 → 1288
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23717
      Location:1066 → 1124
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_001429924.1 → NP_001416853.1  myosin-11 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      E9PTU4

    3. NM_001429925.1 → NP_001416854.1  myosin-11 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      E9PTU4

    4. NM_001429926.1 → NP_001416855.1  myosin-11 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    5. NM_001429927.1 → NP_001416856.1  myosin-11 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K6S9

    6. NM_001429928.1 → NP_001416857.1  myosin-11 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K6S9

    7. NM_001429929.1 → NP_001416858.1  myosin-11 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K6S9

    8. NM_001429930.1 → NP_001416859.1  myosin-11 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZNN9

    9. NM_001429931.1 → NP_001416860.1  myosin-11 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZNN9

    10. NM_001429932.1 → NP_001416861.1  myosin-11 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZNN9

    11. NM_001429933.1 → NP_001416862.1  myosin-11 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    12. NM_001429934.1 → NP_001416863.1  myosin-11 isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      1250554..1345681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085198.2 → XP_038941126.1  myosin-11 isoform X4

      Conserved Domains (3) summary
      cd14921
      Location:99 → 771
      MYSc_Myh11; class II myosin heavy chain 11, motor domain
      pfam01576
      Location:848 → 1928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:33 → 71
      Myosin_N; Myosin N-terminal SH3-like domain

    2. XM_017596998.3 → XP_017452487.1  myosin-11 isoform X3

      Related
      ENSRNOP00000073929.2, ENSRNOT00000087567.3

    3. XM_006245842.5 → XP_006245904.1  myosin-11 isoform X1

      Conserved Domains (7) summary
      cd01377
      Location:99 → 778
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:87 → 778
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:855 → 1935
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:34 → 71
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam16046
      Location:997 → 1089
      FAM76; FAM76 protein
      cl12013
      Location:1166 → 1295
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl15254
      Location:1049 → 1163
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    4. XM_063268409.1 → XP_063124479.1  myosin-11 isoform X2

    5. XM_006245844.5 → XP_006245906.1  myosin-11 isoform X1

      See identical proteins and their annotated locations for XP_006245906.1

      UniProtKB/TrEMBL
      A0A8I6A8G7, E9PTU4
      Conserved Domains (7) summary
      cd01377
      Location:99 → 778
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:87 → 778
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:855 → 1935
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:34 → 71
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam16046
      Location:997 → 1089
      FAM76; FAM76 protein
      cl12013
      Location:1166 → 1295
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl15254
      Location:1049 → 1163
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    6. XM_063268410.1 → XP_063124480.1  myosin-11 isoform X2

    7. XM_017596997.3 → XP_017452486.1  myosin-11 isoform X1

      Related
      ENSRNOP00000074575.2, ENSRNOT00000084608.3
      Conserved Domains (7) summary
      cd01377
      Location:99 → 778
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:87 → 778
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:855 → 1935
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:34 → 71
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam16046
      Location:997 → 1089
      FAM76; FAM76 protein
      cl12013
      Location:1166 → 1295
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl15254
      Location:1049 → 1163
      UBAN; polyubiquitin binding domain of NEMO and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63862.3 GenPept UniProtKB/Swiss-Prot:Q63862

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