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    PDR18 ATP-binding cassette multidrug transporter PDR18 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855807, updated on 17-May-2024

    Summary

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    Gene symbol
    PDR18
    Gene description
    ATP-binding cassette multidrug transporter PDR18
    Primary source
    FungiDB:YNR070W
    Locus tag
    YNR070W
    See related
    SGD:S000005353; AllianceGenome:SGD:S000005353; VEuPathDB:YNR070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ABC-type transporter activity and ATP binding activity. Involved in response to xenobiotic stimulus and sterol homeostasis. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to several human genes including ABCA10 (ATP binding cassette subfamily A member 10); ABCA3 (ATP binding cassette subfamily A member 3); and ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PDR18 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (765375..769376)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bsc5p Neighboring gene aldose 1-epimerase superfamily protein Neighboring gene hexose transporter HXT17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ABC transporter Pdr18 is required for yeast thermotolerance due to its role in ergosterol transport and plasma membrane properties. Godinho CP, et al. Environ Microbiol, 2021 Jan. PMID 32985771, Free PMC Article
    2. Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation. Teixeira MC, et al. Microb Cell Fact, 2012 Jul 27. PMID 22839110, Free PMC Article
    3. The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. Cabrito TR, et al. Biochem J, 2011 Dec 1. PMID 21831043, Free PMC Article
    4. Combined phylogeny and neighborhood analysis of the evolution of the ABC transporters conferring multiple drug resistance in hemiascomycete yeasts. Seret ML, et al. BMC Genomics, 2009 Oct 1. PMID 19796374, Free PMC Article
    5. The Paralogous Genes PDR18 and SNQ2, Encoding Multidrug Resistance ABC Transporters, Derive From a Recent Duplication Event, PDR18 Being Specific to the Saccharomyces Genus. Godinho CP, et al. Front Genet, 2018. PMID 30374366, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ABC transporter Pdr18 is required for yeast thermotolerance due to its role in ergosterol transport and plasma membrane properties.
      Title: The ABC transporter Pdr18 is required for yeast thermotolerance due to its role in ergosterol transport and plasma membrane properties.
    2. results of the present study suggest that Pdr18 plays a role in plasma membrane sterol incorporation, this physiological trait contributing to an MDR phenotype.
      Title: The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-binding cassette multidrug transporter PDR18
    NP_014468.3
    • Transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      765375..769376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183247.4 → NP_014468.3  TPA: ATP-binding cassette multidrug transporter PDR18 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014468.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1P5, P53756
      UniProtKB/TrEMBL
      A0A8H4BYC0, A6ZSE4, B5VR95
      Conserved Domains (1) summary
      TIGR00956
      Location:1 → 1333
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53756.1

    Gene LinkOut

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