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    YET3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851487, updated on 11-Sep-2024

    Summary

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    Official Symbol
    YET3
    Primary source
    SGD:S000002230
    Locus tag
    YDL072C
    See related
    AllianceGenome:SGD:S000002230; FungiDB:YDL072C; VEuPathDB:YDL072C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to several human genes including BCAP31 (B cell receptor associated protein 31). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (329836..330447, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase BRE1 Neighboring gene Ahk1p Neighboring gene Bdf2p Neighboring gene Cbs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. Wilson JD, et al. J Biol Chem, 2010 Jun 11. PMID 20378542, Free PMC Article
    2. Yet1p-Yet3p interacts with Scs2p-Opi1p to regulate ER localization of the Opi1p repressor. Wilson JD, et al. Mol Biol Cell, 2011 May. PMID 21372176, Free PMC Article
    3. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. Sukkurwala AQ, et al. Cell Death Differ, 2014 Jan. PMID 23787997, Free PMC Article
    4. Profiling lipid-protein interactions using nonquenched fluorescent liposomal nanovesicles and proteome microarrays. Lu KY, et al. Mol Cell Proteomics, 2012 Nov. PMID 22843995, Free PMC Article
    5. Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains. Chan JN, et al. Dev Cell, 2011 Jun 14. PMID 21664583

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. show that the Yet1p-Yet3p complex acts in derepression of INO1 through physical association with Scs2p-Opi1p
      Title: Yet1p-Yet3p interacts with Scs2p-Opi1p to regulate ER localization of the Opi1p repressor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yet3p
    NP_010211.1
    • hypothetical protein; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      329836..330447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180131.1 → NP_010211.1  TPA: Yet3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010211.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRS7, P89895, Q07451, Q7LGS8
      UniProtKB/TrEMBL
      B3LGW7, B5VFJ6, C8Z4J7, N1P5S4
      Conserved Domains (1) summary
      COG5374
      Location:1 → 201
      COG5374; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07451.1

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