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    SRD1 Srd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850377, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SRD1
    Official Full Name
    Srd1p
    Primary source
    SGD:S000000611
    Locus tag
    YCR018C
    See related
    AllianceGenome:SGD:S000000611; FungiDB:YCR018C; VEuPathDB:YCR018C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable sequence-specific DNA binding activity and zinc ion binding activity. Involved in rRNA processing. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRD1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (148238..148903, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene RNA-binding ribosome assembly factor RBP95 Neighboring gene Cwh43p Neighboring gene tRNA-Met Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SRD1, a S. cerevisiae gene affecting pre-rRNA processing contains a C2/C2 zinc finger motif. Hess SM, et al. Nucleic Acids Res, 1994 Apr 11. PMID 8165142, Free PMC Article
    2. srd1, a Saccharomyces cerevisiae suppressor of the temperature-sensitive pre-rRNA processing defect of rrp1-1. Fabian GR, et al. Genetics, 1990 Mar. PMID 2179050, Free PMC Article
    3. Sequestration of mRNAs Modulates the Timing of Translation during Meiosis in Budding Yeast. Jin L, et al. Mol Cell Biol, 2015 Oct. PMID 26217015, Free PMC Article
    4. Insights Into the Mechanism of Anticancer Drug Imatinib Revealed Through Multi-Omic Analyses in Yeast. Taymaz-Nikerel H, et al. OMICS, 2020 Nov. PMID 32991258
    5. Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Geertz M, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012409, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Srd1p
    NP_009944.2
    • Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      148238..148903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178731.1 → NP_009944.2  TPA: Srd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009944.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR26, P09007, P09008, Q06989
      UniProtKB/TrEMBL
      C7GT43, C8Z4A5, G2WA34
      Conserved Domains (1) summary
      smart00401
      Location:163 → 214
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09007.2

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