U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CAP1 cyclase associated actin cytoskeleton regulatory protein 1 [ Homo sapiens (human) ]

    Gene ID: 10487, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CAP1provided by HGNC
    Official Full Name
    cyclase associated actin cytoskeleton regulatory protein 1provided by HGNC
    Primary source
    HGNC:HGNC:20040
    See related
    Ensembl:ENSG00000131236 MIM:617801; AllianceGenome:HGNC:20040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP; CAP1-PEN
    Summary
    The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in appendix (RPKM 105.5), lymph node (RPKM 89.3) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CAP1 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40040240..40072648)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (39909560..39942077)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40505912..40538320)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:40363871-40364442 Neighboring gene MYCL antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 716 Neighboring gene MYCL proto-oncogene, bHLH transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40409912-40410434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 823 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40446045-40446898 Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 718 Neighboring gene uncharacterized LOC105378669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 824 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40505419-40506052 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40506053-40506687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40518723-40519222 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:40524580-40525341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:40535511-40536710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 720 Neighboring gene Sharpr-MPRA regulatory region 13734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 829 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40598557-40599056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 830 Neighboring gene uncharacterized LOC105378671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 721 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:40625521-40625722 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40626731-40627347 Neighboring gene OAZ1 pseudogene 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Upregulated expression of CAP1 is associated with tumor migration and metastasis in hepatocellular carcinoma. Liu Y, et al. Pathol Res Pract, 2014 Mar. PMID 24359721
    2. Adenylyl Cyclase-Associated Protein 1: Structure, Regulation, and Participation in Cellular Processes. Kakurina GV, et al. Biochemistry (Mosc), 2018 Jan. PMID 29534668
    3. Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma. Fan YC, et al. Oncol Rep, 2016 Sep. PMID 27432289
    4. CAP1 (Cyclase-Associated Protein 1) Exerts Distinct Functions in the Proliferation and Metastatic Potential of Breast Cancer Cells Mediated by ERK. Zhang H, et al. Sci Rep, 2016 May 13. PMID 27173014, Free PMC Article
    5. High expression of adenylate cyclase-associated protein 1 accelerates the proliferation, migration and invasion of neural glioma cells. Bao Z, et al. Pathol Res Pract, 2016 Apr. PMID 26810579

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function.
      Title: Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function.
    2. Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion.
      Title: Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion.
    3. Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.
      Title: Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.
    4. Novel role of CAP1 in regulation RNA polymerase II-mediated transcription elongation depends on its actin-depolymerization activity in nucleoplasm.
      Title: Novel role of CAP1 in regulation RNA polymerase II-mediated transcription elongation depends on its actin-depolymerization activity in nucleoplasm.
    5. Relationship of intracellular proteolysis with CAP1 and cofilin1 in non-small-cell lung cancer.
      Title: Relationship of intracellular proteolysis with CAP1 and cofilin1 in non-small-cell lung cancer.
    6. Serum Resistin, Adenylate Cyclase-Associated Protein 1 Gene Expression, and Carotid Intima-Media Thickness in Patients with End-Stage Renal Disease and Healthy Controls.
      Title: Serum Resistin, Adenylate Cyclase-Associated Protein 1 Gene Expression, and Carotid Intima-Media Thickness in Patients with End-Stage Renal Disease and Healthy Controls.
    7. Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer.
      Title: Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer.
    8. Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells.
      Title: Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells.
    9. Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms.
      Title: Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms.
    10. this study provides direct cellular evidence that transient phosphorylation is required for CAP1 functions in both actin filament turnover and adhesion, and the novel mechanistic insights substantially extend our knowledge of the cell signals that function in concert to regulate CAP1 by facilitating its transient phosphorylation.
      Title: Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ameboidal-type cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adenylyl cyclase-associated protein 1
    Names
    CAP, adenylate cyclase-associated protein 1
    adenylate cyclase associated protein 1
    testis secretory sperm-binding protein Li 218p

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105530.2 → NP_001099000.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361883.3, ENST00000372797.7
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    2. NM_001330502.2 → NP_001317431.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000344832.3, ENST00000340450.7
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    3. NM_001350475.2 → NP_001337404.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    4. NM_001350476.2 → NP_001337405.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    5. NM_001350477.3 → NP_001337406.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361878.2, ENST00000372792.7
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    6. NM_001350478.2 → NP_001337407.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    7. NM_001350479.2 → NP_001337408.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    8. NM_001350480.2 → NP_001337409.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    9. NM_001350481.2 → NP_001337410.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    10. NM_001350482.2 → NP_001337411.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361884.1, ENST00000372798.5
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    11. NM_001350483.2 → NP_001337412.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361888.1, ENST00000372802.5
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    12. NM_001350484.2 → NP_001337413.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    13. NM_001350485.2 → NP_001337414.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    14. NM_006367.4 → NP_006358.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361891.3, ENST00000372805.8
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40040240..40072648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431628.1 → XP_047287584.1  adenylyl cyclase-associated protein 1 isoform X2

    2. XM_047431636.1 → XP_047287592.1  adenylyl cyclase-associated protein 1 isoform X2

    3. XM_047431520.1 → XP_047287476.1  adenylyl cyclase-associated protein 1 isoform X2

    4. XM_047431420.1 → XP_047287376.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6

    5. XM_011540515.2 → XP_011538817.1  adenylyl cyclase-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011538817.1

      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    6. XM_011540510.2 → XP_011538812.1  adenylyl cyclase-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538812.1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    7. XM_047431603.1 → XP_047287559.1  adenylyl cyclase-associated protein 1 isoform X2

    8. XM_017000069.2 → XP_016855558.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 62
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319 → 473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    9. XM_047431580.1 → XP_047287536.1  adenylyl cyclase-associated protein 1 isoform X2

    10. XM_047431489.1 → XP_047287445.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6

    11. XM_047431616.1 → XP_047287572.1  adenylyl cyclase-associated protein 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      39909560..39942077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333863.1 → XP_054189838.1  adenylyl cyclase-associated protein 1 isoform X2

    2. XM_054333864.1 → XP_054189839.1  adenylyl cyclase-associated protein 1 isoform X2

    3. XM_054333858.1 → XP_054189833.1  adenylyl cyclase-associated protein 1 isoform X2

    4. XM_054333854.1 → XP_054189829.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      D3DPU2

    5. XM_054333859.1 → XP_054189834.1  adenylyl cyclase-associated protein 1 isoform X2

    6. XM_054333856.1 → XP_054189831.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      D3DPU2

    7. XM_054333861.1 → XP_054189836.1  adenylyl cyclase-associated protein 1 isoform X2

    8. XM_054333855.1 → XP_054189830.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      D3DPU2

    9. XM_054333860.1 → XP_054189835.1  adenylyl cyclase-associated protein 1 isoform X2

    10. XM_054333857.1 → XP_054189832.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      D3DPU2

    11. XM_054333862.1 → XP_054189837.1  adenylyl cyclase-associated protein 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01518.5 GenPept UniProtKB/Swiss-Prot:Q01518

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous