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    Ddx23 DEAD box helicase 23 [ Mus musculus (house mouse) ]

    Gene ID: 74351, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ddx23provided by MGI
    Official Full Name
    DEAD box helicase 23provided by MGI
    Primary source
    MGI:MGI:1921601
    See related
    Ensembl:ENSMUSG00000003360 AllianceGenome:MGI:1921601
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110082M05Rik; 4921506D17Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in R-loop processing and mRNA splicing, via spliceosome. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and catalytic step 2 spliceosome. Orthologous to human DDX23 (DEAD-box helicase 23). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 28.2), thymus adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx23 in Genome Data Viewer
    Location:
    15 F1; 15 54.65 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98543012..98560808, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98645379..98662928, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 11 Neighboring gene adenylate cyclase 6 Neighboring gene STARR-seq mESC enhancer starr_39665 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98440580-98440763 Neighboring gene STARR-positive B cell enhancer ABC_E9921 Neighboring gene STARR-seq mESC enhancer starr_39668 Neighboring gene calcium channel, voltage-dependent, beta 3 subunit Neighboring gene STARR-positive B cell enhancer ABC_E8612 Neighboring gene STARR-positive B cell enhancer ABC_E9922 Neighboring gene Rho family GTPase 1 Neighboring gene predicted gene, 34152

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
    2. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in R-loop processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX23
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
    NP_001074450.1
    XP_006521556.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080981.1 → NP_001074450.1  probable ATP-dependent RNA helicase DDX23

      See identical proteins and their annotated locations for NP_001074450.1

      Status: PROVISIONAL

      Source sequence(s)
      AC156543
      Consensus CDS
      CCDS37193.1
      UniProtKB/TrEMBL
      D3Z0M9
      Related
      ENSMUSP00000003450.9, ENSMUST00000003450.15
      Conserved Domains (4) summary
      TIGR01622
      Location:79 → 207
      SF-CC1; splicing factor, CC1-like family
      cd18787
      Location:638 → 767
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17945
      Location:401 → 627
      DEADc_DDX23; DEAD-box helicase domain of DEAD box protein 23
      pfam17380
      Location:163 → 350
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98543012..98560808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521493.5 → XP_006521556.1  probable ATP-dependent RNA helicase DDX23 isoform X1

      See identical proteins and their annotated locations for XP_006521556.1

      UniProtKB/TrEMBL
      D3Z0M9
      Conserved Domains (4) summary
      TIGR01622
      Location:79 → 207
      SF-CC1; splicing factor, CC1-like family
      cd18787
      Location:638 → 767
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17945
      Location:401 → 627
      DEADc_DDX23; DEAD-box helicase domain of DEAD box protein 23
      pfam17380
      Location:163 → 350
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version

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