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    Fbxo34 F-box protein 34 [ Mus musculus (house mouse) ]

    Gene ID: 78938, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Fbxo34provided by MGI
    Official Full Name
    F-box protein 34provided by MGI
    Primary source
    MGI:MGI:1926188
    See related
    Ensembl:ENSMUSG00000037536 AllianceGenome:MGI:1926188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900057B08Rik; 5830426G16Rik
    Summary
    Is expressed in liver. Orthologous to human FBXO34 (F-box protein 34). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.2), liver E14.5 (RPKM 10.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo34 in Genome Data Viewer
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47709992..47769419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47472533..47531962)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DLG associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E606 Neighboring gene ribosomal protein S15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36580 Neighboring gene predicted gene, 35166 Neighboring gene autophagy related 14 Neighboring gene STARR-positive B cell enhancer ABC_E9894 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    2. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146085.1 → NP_001139557.1  F-box only protein 34 isoform 2

      See identical proteins and their annotated locations for NP_001139557.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes two alternate segments which result in the use of a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform 2) which is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC123665, AK020018, CB575943
      Consensus CDS
      CCDS49471.1
      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Related
      ENSMUSP00000131708.2, ENSMUST00000163324.8
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    2. NM_001146086.1 → NP_001139558.1  F-box only protein 34 isoform 2

      See identical proteins and their annotated locations for NP_001139558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate segment which results in the use of a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform 2) which is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK020018, BB703607, BC049155
      Consensus CDS
      CCDS49471.1
      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Related
      ENSMUSP00000132271.2, ENSMUST00000168833.9
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    3. NM_030236.3 → NP_084512.2  F-box only protein 34 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK020018, BB703607, BC049155
      Consensus CDS
      CCDS26988.1
      UniProtKB/TrEMBL
      E9QM55, Q3TAU3
      Related
      ENSMUSP00000044675.8, ENSMUST00000043112.9
      Conserved Domains (1) summary
      cl45894
      Location:610 → 657
      F-box_SF; F-box domain superfamily

    RNA

    1. NR_027414.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains four alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK013711, AK020018, BB703607, BC049155
      Related
      ENSMUST00000228019.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47709992..47769419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519723.5 → XP_006519786.2  F-box only protein 34 isoform X1

      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam12937
      Location:711 → 745
      F-box-like

    2. XM_006519710.2 → XP_006519773.1  F-box only protein 34 isoform X2

      See identical proteins and their annotated locations for XP_006519773.1

      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam12937
      Location:579 → 613
      F-box-like

    3. XM_036158918.1 → XP_036014811.1  F-box only protein 34 isoform X3

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    4. XM_030248097.2 → XP_030103957.1  F-box only protein 34 isoform X3

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    5. XM_017316225.3 → XP_017171714.1  F-box only protein 34 isoform X3

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    6. XM_006519722.1 → XP_006519785.1  F-box only protein 34 isoform X3

      See identical proteins and their annotated locations for XP_006519785.1

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    7. XM_036158916.1 → XP_036014809.1  F-box only protein 34 isoform X3

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    8. XM_006519713.2 → XP_006519776.1  F-box only protein 34 isoform X3

      See identical proteins and their annotated locations for XP_006519776.1

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Related
      ENSMUSP00000093634.3, ENSMUST00000095941.9
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    9. XM_036158919.1 → XP_036014812.1  F-box only protein 34 isoform X3

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    10. XM_006519717.3 → XP_006519780.1  F-box only protein 34 isoform X3

      See identical proteins and their annotated locations for XP_006519780.1

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    11. XM_006519718.4 → XP_006519781.1  F-box only protein 34 isoform X3

      See identical proteins and their annotated locations for XP_006519781.1

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    12. XM_006519714.1 → XP_006519777.1  F-box only protein 34 isoform X3

      See identical proteins and their annotated locations for XP_006519777.1

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Related
      ENSMUSP00000130036.2, ENSMUST00000165714.2
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    13. XM_006519720.1 → XP_006519783.1  F-box only protein 34 isoform X3

      See identical proteins and their annotated locations for XP_006519783.1

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    14. XM_006519712.5 → XP_006519775.1  F-box only protein 34 isoform X2

      See identical proteins and their annotated locations for XP_006519775.1

      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam12937
      Location:579 → 613
      F-box-like

    15. XM_006519719.2 → XP_006519782.1  F-box only protein 34 isoform X3

      See identical proteins and their annotated locations for XP_006519782.1

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain

    16. XM_036158917.1 → XP_036014810.1  F-box only protein 34 isoform X3

      UniProtKB/Swiss-Prot
      Q80XI1, Q9D290
      UniProtKB/TrEMBL
      Q3TAU3
      Conserved Domains (1) summary
      pfam00646
      Location:561 → 593
      F-box; F-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XI1.2 GenPept UniProtKB/Swiss-Prot:Q80XI1

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