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    Chid1 chitinase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68038, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Chid1provided by MGI
    Official Full Name
    chitinase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915288
    See related
    Ensembl:ENSMUSG00000025512 AllianceGenome:MGI:1915288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110023E09Rik
    Summary
    Predicted to enable oligosaccharide binding activity. Predicted to be involved in negative regulation of cytokine production involved in inflammatory response. Predicted to be located in several cellular components, including late endosome; lysosome; and trans-Golgi network. Predicted to be active in endomembrane system. Orthologous to human CHID1 (chitinase domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 13.0), placenta adult (RPKM 12.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chid1 in Genome Data Viewer
    Location:
    7 F5; 7 86.86 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141073049..141119818, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141493136..141539905, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10575 Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene CD151 antigen Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene tetraspanin 4 Neighboring gene STARR-seq mESC enhancer starr_20492 Neighboring gene STARR-seq mESC enhancer starr_20493 Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene STARR-positive B cell enhancer ABC_E2855 Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chitinase domain-containing protein 1
    NP_001136153.2
    NP_001356279.1
    NP_001356280.1
    NP_001356281.1
    NP_080798.3
    XP_006536294.1
    XP_011248152.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142681.2 → NP_001136153.2  chitinase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AK050655, BC006876, BE953974, BY101128
      Consensus CDS
      CCDS52447.2
      UniProtKB/Swiss-Prot
      Q3TVF7, Q6P8U4, Q8C7C5, Q922Q9, Q9CXR7
      UniProtKB/TrEMBL
      A0A0R4J242
      Related
      ENSMUSP00000114693.2, ENSMUST00000153191.8
      Conserved Domains (1) summary
      cd02876
      Location:77 → 393
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

    2. NM_001369350.1 → NP_001356279.1  chitinase domain-containing protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC158224
      UniProtKB/TrEMBL
      A0A0R4J242
      Conserved Domains (1) summary
      cd02876
      Location:77 → 359
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

    3. NM_001369351.1 → NP_001356280.1  chitinase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. It encodes the longest isoform (1). Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS52447.2
      UniProtKB/Swiss-Prot
      Q3TVF7, Q6P8U4, Q8C7C5, Q922Q9, Q9CXR7
      UniProtKB/TrEMBL
      A0A0R4J242
      Conserved Domains (1) summary
      cd02876
      Location:77 → 393
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

    4. NM_001369352.1 → NP_001356281.1  chitinase domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS52447.2
      UniProtKB/Swiss-Prot
      Q3TVF7, Q6P8U4, Q8C7C5, Q922Q9, Q9CXR7
      UniProtKB/TrEMBL
      A0A0R4J242
      Conserved Domains (1) summary
      cd02876
      Location:77 → 393
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

    5. NM_026522.6 → NP_080798.3  chitinase domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC158224, AK050655, BE953974, BY101128
      Consensus CDS
      CCDS22019.2
      UniProtKB/TrEMBL
      A0A0R4J058
      Related
      ENSMUSP00000112891.2, ENSMUST00000118694.8
      Conserved Domains (1) summary
      cd02876
      Location:77 → 307
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141073049..141119818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249850.4 → XP_011248152.1  chitinase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      D3YWG2
      Related
      ENSMUSP00000115174.2, ENSMUST00000143561.2
      Conserved Domains (1) summary
      cd02876
      Location:80 → 322
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

    2. XM_006536231.4 → XP_006536294.1  chitinase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006536294.1

      UniProtKB/TrEMBL
      A0A0R4J242
      Conserved Domains (1) summary
      cd02876
      Location:80 → 323
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922Q9.1 GenPept UniProtKB/Swiss-Prot:Q922Q9

    Gene LinkOut

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