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    L3hypdh L-3-hydroxyproline dehydratase (trans-) [ Mus musculus (house mouse) ]

    Gene ID: 67217, updated on 28-Oct-2024

    Summary

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    Official Symbol
    L3hypdhprovided by MGI
    Official Full Name
    L-3-hydroxyproline dehydratase (trans-)provided by MGI
    Primary source
    MGI:MGI:1914467
    See related
    Ensembl:ENSMUSG00000019718 AllianceGenome:MGI:1914467
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810055F11Rik
    Summary
    Enables hydro-lyase activity. Orthologous to human L3HYPDH (trans-L-3-hydroxyproline dehydratase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in adrenal adult (RPKM 31.4), ovary adult (RPKM 18.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See L3hypdh in Genome Data Viewer
    Location:
    12 C3; 12 30.2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (72114745..72132206, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (72069518..72085433, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40440 Neighboring gene STARR-seq mESC enhancer starr_32432 Neighboring gene predicted gene 7986 Neighboring gene G protein-coupled receptor 135 Neighboring gene STARR-seq mESC enhancer starr_32433 Neighboring gene predicted gene 3225 Neighboring gene STARR-positive B cell enhancer ABC_E3055 Neighboring gene JNK1/MAPK8-associated membrane protein Neighboring gene predicted gene, 19135 Neighboring gene coiled-coil domain containing 175 Neighboring gene zinc finger protein 146 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH. Liu J, et al. Virus Res, 2024 Apr. PMID 38342315, Free PMC Article
    2. Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes. Visser WF, et al. J Biol Chem, 2012 Jun 22. PMID 22528483, Free PMC Article
    3. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH.
      Title: Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydro-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydro-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables proline racemase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables trans-L-3-hydroxyproline dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    trans-L-3-hydroxyproline dehydratase
    Names
    probable proline racemase
    trans-3-hydroxy-l-proline dehydratase
    NP_080314.1
    XP_011242463.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026038.2 → NP_080314.1  trans-L-3-hydroxyproline dehydratase

      See identical proteins and their annotated locations for NP_080314.1

      Status: PROVISIONAL

      Source sequence(s)
      AK018449
      Consensus CDS
      CCDS25966.1
      UniProtKB/Swiss-Prot
      B8JJ82, Q99KB5, Q9CXA2
      Related
      ENSMUSP00000019862.3, ENSMUST00000019862.3
      Conserved Domains (2) summary
      PRK13970
      Location:20 → 347
      PRK13970; hydroxyproline-2-epimerase; Provisional
      pfam05544
      Location:22 → 352
      Pro_racemase; Proline racemase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      72114745..72132206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244161.4 → XP_011242463.1  trans-L-3-hydroxyproline dehydratase isoform X1

      Conserved Domains (1) summary
      pfam05544
      Location:22 → 314
      Pro_racemase; Proline racemase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXA2.1 GenPept UniProtKB/Swiss-Prot:Q9CXA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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