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    Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 [ Mus musculus (house mouse) ]

    Gene ID: 68202, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ndufa5provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A5provided by MGI
    Primary source
    MGI:MGI:1915452
    See related
    Ensembl:ENSMUSG00000023089 AllianceGenome:MGI:1915452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-13kD-B; 2900002J19Rik
    Summary
    Acts upstream of or within respiratory electron transport chain. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including alimentary system; brown fat; liver; nervous system; and urinary system. Orthologous to human NDUFA5 (NADH:ubiquinone oxidoreductase subunit A5). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in heart adult (RPKM 29.1), cerebellum adult (RPKM 24.8) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufa5 in Genome Data Viewer
    Location:
    6 A3.1; 6 11.28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (24518661..24527689, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (24518662..24527690, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15351 Neighboring gene zinc finger and SCAN domain containing 5B pseudogene Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene STARR-positive B cell enhancer mm9_chr6:24477506-24477807 Neighboring gene STARR-positive B cell enhancer ABC_E2778 Neighboring gene ankyrin repeat and SOCS box-containing 15 Neighboring gene leiomodin 2 (cardiac)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5. Nie H, et al. J Cell Mol Med, 2018 Dec. PMID 30324697, Free PMC Article
    2. Identification of NADH dehydrogenase 1 alpha subcomplex 5 capable to transform murine fibroblasts and overexpressed in human cervical carcinoma cell lines. Shimada T, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16329995
    3. Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Peralta S, et al. Hum Mol Genet, 2014 Mar 15. PMID 24154540, Free PMC Article
    4. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article
    5. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Through bioinformatics prediction, we found miR-33a directly targeted on the 3'-UTR of NDUFA5. Dual-luciferase reporter analysis further confirmed the direct suppression of miR-33a on NDUFA5 expression
      Title: Hepatocyte miR-33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5.
    2. At the age of 11 months, mice with a central nervous system knockout of Ndufa5 (Ndufa5 CNS-KO) showed lethargy and loss of motor skills. In these mice cortices, the levels of NDUFA5 protein were reduced to 25% of controls. Fully assembled complex I (CI) levels were also greatly reduced in cortex and CI activity in homogenates was reduced to 60% of controls.
      Title: Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage.
    3. The real-time RT-PCR analysis revealed that the expressions of the NDUFA5 mRNA, but not the ZNF9 mRNA level, were significantly up-regulated in all the tested cell lines derived from HPV-positive cervical cancer, HeLa, SW576, and CaSKi.
      Title: Identification of NADH dehydrogenase 1 alpha subcomplex 5 capable to transform murine fibroblasts and overexpressed in human cervical carcinoma cell lines.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within respiratory electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
    NADH-ubiquinone oxidoreductase 13 kDa-B subunit
    complex I subunit B13
    complex I-13kD-B
    NP_001297997.1
    NP_080890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311068.2 → NP_001297997.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 2

      See identical proteins and their annotated locations for NP_001297997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AC153635, BY247454, BY253904, W66892
      Consensus CDS
      CCDS80494.1
      UniProtKB/TrEMBL
      D3YTQ8
      Related
      ENSMUSP00000112971.2, ENSMUST00000118558.5

    2. NM_026614.3 → NP_080890.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1

      See identical proteins and their annotated locations for NP_080890.1

      Status: VALIDATED

      Source sequence(s)
      AK019301, BY253904, W66892
      Consensus CDS
      CCDS19942.1
      UniProtKB/Swiss-Prot
      Q9CPP6, Q9CY90, Q9D2P2, Q9D703, Q9D739
      UniProtKB/TrEMBL
      Q9CX78
      Related
      ENSMUSP00000023851.6, ENSMUST00000023851.9
      Conserved Domains (1) summary
      pfam04716
      Location:13 → 78
      ETC_C1_NDUFA5; ETC complex I subunit conserved region

    RNA

    1. NR_154219.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153635, AC155284
      Related
      ENSMUST00000141274.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      24518661..24527689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPP6.3 GenPept UniProtKB/Swiss-Prot:Q9CPP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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