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    Gtpbp8 GTP-binding protein 8 (putative) [ Mus musculus (house mouse) ]

    Gene ID: 66067, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gtpbp8provided by MGI
    Official Full Name
    GTP-binding protein 8 (putative)provided by MGI
    Primary source
    MGI:MGI:1913317
    See related
    Ensembl:ENSMUSG00000022668 AllianceGenome:MGI:1913317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610037H22Rik
    Summary
    Predicted to enable GTP binding activity and metal ion binding activity. Located in mitochondrion. Orthologous to human GTPBP8 (GTP binding protein 8). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 6.8), CNS E18 (RPKM 6.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtpbp8 in Genome Data Viewer
    Location:
    16 B4; 16 29.05 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44559242..44566726, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44738879..44746363, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30311 Neighboring gene VISTA enhancer mm1637 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:44692039-44692222 Neighboring gene STARR-seq mESC enhancer starr_40911 Neighboring gene STARR-positive B cell enhancer ABC_E10905 Neighboring gene predicted gene, 30445 Neighboring gene nucleolus and neural progenitor protein Neighboring gene STARR-positive B cell enhancer mm9_chr16:44746411-44746712 Neighboring gene STARR-positive B cell enhancer ABC_E5543 Neighboring gene CD200 receptor 1 Neighboring gene lactate dehydrogenase A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic analysis of the upper lip and primary palate development in mice. Cai S, et al. Front Genet, 2022. PMID 36685938, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130125, MGC130126

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159329.1 → NP_001152801.1  GTP-binding protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001152801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC107217, BE197762, CJ169587
      Consensus CDS
      CCDS49855.1
      UniProtKB/Swiss-Prot
      Q9CY28
      Related
      ENSMUSP00000023348.5, ENSMUST00000023348.11
      Conserved Domains (2) summary
      cd01876
      Location:47 → 214
      YihA_EngB; YihA (EngB) GTPase family
      TIGR00231
      Location:46 → 203
      small_GTP; small GTP-binding protein domain

    2. NM_001356392.1 → NP_001343321.1  GTP-binding protein 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122217
      UniProtKB/TrEMBL
      F6XXP5
      Related
      ENSMUSP00000123974.2, ENSMUST00000161436.2
      Conserved Domains (1) summary
      cd01876
      Location:114 → 248
      YihA_EngB; YihA (EngB) GTPase family

    3. NM_025332.3 → NP_079608.1  GTP-binding protein 8 isoform 1

      See identical proteins and their annotated locations for NP_079608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK147840, BE197762, CJ169587
      Consensus CDS
      CCDS28188.1
      UniProtKB/Swiss-Prot
      Q3KNM0, Q9CY28
      UniProtKB/TrEMBL
      F6XXP5
      Related
      ENSMUSP00000125352.2, ENSMUST00000162512.8
      Conserved Domains (2) summary
      cd01876
      Location:113 → 281
      YihA_EngB; YihA (EngB) GTPase family
      pfam00009
      Location:114 → 273
      GTP_EFTU; Elongation factor Tu GTP binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44559242..44566726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY28.1 GenPept UniProtKB/Swiss-Prot:Q9CY28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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