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    Skp2 S-phase kinase-associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 27401, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Skp2provided by MGI
    Official Full Name
    S-phase kinase-associated protein 2provided by MGI
    Primary source
    MGI:MGI:1351663
    See related
    Ensembl:ENSMUSG00000054115 AllianceGenome:MGI:1351663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p45; FWD1; FBXL1; 4930500A04Rik
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of double-strand break repair via homologous recombination and protein K63-linked ubiquitination. Acts upstream of or within several processes, including mitotic cell cycle phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of protein polyubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including blastocyst; brain; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis adult (RPKM 26.1), limb E14.5 (RPKM 12.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Skp2 in Genome Data Viewer
    Location:
    15 A1; 15 3.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (9112070..9155512, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (9111982..9155425, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 3-like Neighboring gene predicted gene, 53883 Neighboring gene STARR-positive B cell enhancer ABC_E1904 Neighboring gene STARR-seq mESC enhancer starr_37924 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3131 Neighboring gene LMBR1 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_37931 Neighboring gene STARR-seq mESC enhancer starr_37932 Neighboring gene UDP glycosyltransferases 3 family pseudogene Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Imaki H, et al. Cancer Res, 2003 Aug 1. PMID 12907639
    2. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Li X, et al. Oncotarget, 2015 Dec 8. PMID 26497688, Free PMC Article
    3. The miR-30 Family Inhibits Pulmonary Vascular Hyperpermeability in the Premetastatic Phase by Direct Targeting of Skp2. Qi F, et al. Clin Cancer Res, 2015 Jul 1. PMID 25810374
    4. Hormonal induction of adipogenesis induces Skp2 expression through PI3K and MAPK pathways. Auld CA, et al. J Cell Biochem, 2007 Jan 1. PMID 16924675
    5. The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo. Cooke PS, et al. Obesity (Silver Spring), 2007 Jun. PMID 17557977

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
      Title: SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
    2. A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.
      Title: A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.
    3. Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
      Title: Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
    4. AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
      Title: AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
    5. SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis.
      Title: SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis.
    6. The role of SCF(Skp2) and SCF(beta-TrCP1/2) in the cerebellar granule cell precursors.
      Title: The role of SCF(Skp2) and SCF(β-TrCP1/2) in the cerebellar granule cell precursors.
    7. S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
      Title: S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
    8. MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
      Title: MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
    9. Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
      Title: Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
    10. Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.
      Title: Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.
    Submit: New GeneRIF Correction See all GeneRIFs (83)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102075, MGC116668, 4930500A04Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-phase kinase-associated protein 2
    Names
    F-box protein Skp2
    F-box/WD-40 protein 1
    cyclin A/CDK2-associated protein p45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285980.1 → NP_001272909.1  S-phase kinase-associated protein 2 isoform c

      See identical proteins and their annotated locations for NP_001272909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC139209, AK006221, AK015652, BC092236
      Consensus CDS
      CCDS79360.1
      UniProtKB/TrEMBL
      A0A087WQ11
      Related
      ENSMUSP00000139997.2, ENSMUST00000190131.2
      Conserved Domains (3) summary
      cd09293
      Location:158 → 310
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:102 → 132
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:62 → 107
      F-box-like; F-box-like

    2. NM_013787.3 → NP_038815.1  S-phase kinase-associated protein 2 isoform a

      See identical proteins and their annotated locations for NP_038815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC139209, AK166034, BY740905
      Consensus CDS
      CCDS37037.1
      UniProtKB/Swiss-Prot
      Q8BSG7, Q8C8Y9, Q8CB22, Q99J53, Q9Z0Z3
      UniProtKB/TrEMBL
      Q569Z9
      Related
      ENSMUSP00000094225.4, ENSMUST00000096482.10
      Conserved Domains (3) summary
      cd09293
      Location:193 → 345
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:137 → 167
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:97 → 142
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      9112070..9155512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245359.3 → XP_011243661.1  S-phase kinase-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243661.1

      Conserved Domains (3) summary
      cd09293
      Location:203 → 355
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:147 → 177
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:107 → 151
      F-box-like

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145468.1: Suppressed sequence

      Description
      NM_145468.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0Z3.1 GenPept UniProtKB/Swiss-Prot:Q9Z0Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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