U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GAP43 growth associated protein 43 [ Homo sapiens (human) ]

    Gene ID: 2596, updated on 9-Dec-2024

    Summary

    Official Symbol
    GAP43provided by HGNC
    Official Full Name
    growth associated protein 43provided by HGNC
    Primary source
    HGNC:HGNC:4140
    See related
    Ensembl:ENSG00000172020 MIM:162060; AllianceGenome:HGNC:4140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B-50; PP46; GAP-43
    Summary
    The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 55.1) and appendix (RPKM 1.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GAP43 in Genome Data Viewer
    Location:
    3q13.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (115623510..115721483)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (118343657..118441697)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (115342357..115440330)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:115003756-115004955 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:115036984-115037582 Neighboring gene eukaryotic translation initiation factor 4E family member 2 pseudogene 2 Neighboring gene uncharacterized LOC105374051 Neighboring gene NANOG hESC enhancer GRCh37_chr3:115193927-115194488 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:115237315-115237868 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:115333844-115334395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:115376638-115377510 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:115377511-115378382 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:115417888-115418741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:115431872-115432372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:115432373-115432873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:115502891-115503391 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:115503423-115504101 Neighboring gene uncharacterized LOC124909412 Neighboring gene uncharacterized LOC124906269 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:115511955-115512480 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:115512481-115513006 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:115513007-115513531 Neighboring gene NANOG hESC enhancer GRCh37_chr3:115513693-115514194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:115514334-115515272 Neighboring gene 3q13.2-q13.31 distal HERV-H recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:115515273-115516210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:115517565-115518070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20285 Neighboring gene RNA, 7SL, cytoplasmic 815, pseudogene Neighboring gene limbic system associated membrane protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of growth associated protein 43 (GAP43) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysophosphatidic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon choice point recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in radial glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic specialization assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to auditory stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in tissue regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuromodulin
    Names
    axonal membrane protein GAP-43
    calmodulin-binding protein P-57
    nerve growth-related peptide GAP43
    neural phosphoprotein B-50
    neuron growth-associated protein 43
    protein F1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130064.2NP_001123536.1  neuromodulin isoform 1

      See identical proteins and their annotated locations for NP_001123536.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK289699, BX648458
      Consensus CDS
      CCDS46890.1
      UniProtKB/Swiss-Prot
      P17677
      Related
      ENSP00000377372.3, ENST00000393780.3
      Conserved Domains (3) summary
      smart00015
      Location:6688
      IQ; Calmodulin-binding motif
      pfam06614
      Location:107274
      Neuromodulin; Neuromodulin
      pfam10310
      Location:89203
      DUF2413; Protein of unknown function (DUF2413)
    2. NM_002045.4NP_002036.1  neuromodulin isoform 2

      See identical proteins and their annotated locations for NP_002036.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon and has an upstream AUG start codon, as compared to variant 1. The resulting isoform 2 has a shorter and distinct N-terminus, as compared to variant 1.
      Source sequence(s)
      AK123311, AK313658, BX648458, DA701390
      Consensus CDS
      CCDS33830.1
      UniProtKB/Swiss-Prot
      A8K0Y4, P17677
      UniProtKB/TrEMBL
      Q5U058
      Related
      ENSP00000305010.7, ENST00000305124.11
      Conserved Domains (2) summary
      smart00015
      Location:3052
      IQ; Calmodulin-binding motif
      pfam06614
      Location:67238
      Neuromodulin; Neuromodulin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      115623510..115721483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      118343657..118441697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)