U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    BCL2L10 BCL2 like 10 [ Homo sapiens (human) ]

    Gene ID: 10017, updated on 9-Dec-2024

    Summary

    Official Symbol
    BCL2L10provided by HGNC
    Official Full Name
    BCL2 like 10provided by HGNC
    Primary source
    HGNC:HGNC:993
    See related
    Ensembl:ENSG00000137875 MIM:606910; AllianceGenome:HGNC:993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Boo; Diva; BCL-B; bcl2-L-10
    Summary
    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in skin (RPKM 2.0), kidney (RPKM 1.9) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BCL2L10 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (52109263..52112775, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (49917909..49921421, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52401460..52404972, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268150 Neighboring gene uncharacterized LOC124903494 Neighboring gene MAPK6-RPS13P8 intergenic CAGE-defined mid-level expression enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr15:52386957-52387157 Neighboring gene Sharpr-MPRA regulatory region 14256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9422 Neighboring gene ribosomal protein S13 pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9423 Neighboring gene G protein subunit beta 5 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52472339-52472840 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52483687-52484186 Neighboring gene competing endogenous lncRNA 1 for miR-4707-5p and miR-4767 Neighboring gene myosin VC Neighboring gene uncharacterized LOC105370820 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:52521219-52521393

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129810, MGC129811

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables caspase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female gamete generation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule organizing center organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    bcl-2-like protein 10
    Names
    BCL2-like 10 (apoptosis facilitator)
    anti-apoptotic protein Boo
    anti-apoptotic protein NrH
    apoptosis regulator Bcl-B
    death inducer binding to vBcl-2 and Apaf-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306168.1NP_001293097.1  bcl-2-like protein 10 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC023906, AF326964, BC143227, BX119239
      Consensus CDS
      CCDS76756.1
      UniProtKB/TrEMBL
      H0YMD5
      Related
      ENSP00000453562.1, ENST00000561198.1
      Conserved Domains (1) summary
      cd06845
      Location:16164
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    2. NM_020396.4NP_065129.1  bcl-2-like protein 10 isoform 2

      See identical proteins and their annotated locations for NP_065129.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC023906
      Consensus CDS
      CCDS10148.1
      UniProtKB/Swiss-Prot
      Q3SX80, Q52LQ9, Q8TCS9, Q9HD36
      Related
      ENSP00000260442.3, ENST00000260442.3
      Conserved Domains (1) summary
      cd06845
      Location:16169
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      52109263..52112775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      49917909..49921421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)