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    MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens (human) ]

    Gene ID: 5608, updated on 3-Dec-2024

    Summary

    Official Symbol
    MAP2K6provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase 6provided by HGNC
    Primary source
    HGNC:HGNC:6846
    See related
    Ensembl:ENSG00000108984 MIM:601254; AllianceGenome:HGNC:6846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
    Summary
    This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAP2K6 in Genome Data Viewer
    Location:
    17q24.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (69414697..69553865)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (70291653..70430810)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (67410838..67550006)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371878 Neighboring gene uncharacterized LOC124900401 Neighboring gene uncharacterized LOC105371879 Neighboring gene Sharpr-MPRA regulatory region 9140 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67425744-67426560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12654 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67443780-67444760 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67444761-67445742 Neighboring gene uncharacterized LOC105371880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12656 Neighboring gene NANOG hESC enhancer GRCh37_chr17:67502478-67502979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:67565237-67565738 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:67603079-67604278 Neighboring gene long intergenic non-protein coding RNA 1483 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:67757718-67758917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67797333-67798295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67798296-67799257 Neighboring gene MPRA-validated peak2972 silencer Neighboring gene MPRA-validated peak2973 silencer Neighboring gene long intergenic non-protein coding RNA 1497

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    EBI GWAS Catalog
    Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription PubMed
    tat The association of HIV-1 Tat with MAP2K6 promoter leads to the activation of this kinase in immature dendritic cells and in monocyte-derived macrophages PubMed
    tat MAP2K6 and IRF7 induce HIV-1 Tat-mediated cellular gene modulation through the p38 MAPK/STAT1 pathway in immature dendritic cells and in monocyte-derived macrophages PubMed
    tat SiRNA-mediated inhibition of MAP2K6 and MAP2K3 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to sorbitol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovulation cycle process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in p38MAPK cascade TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of prostaglandin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction in response to DNA damage TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stress-activated protein kinase signaling cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 6
    Names
    MAPK/ERK kinase 6
    MAPKK 6
    MEK 6
    SAPK kinase 3
    protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
    stress-activated protein kinase kinase 3
    NP_001317379.1
    NP_002749.2
    XP_005257573.1
    XP_006722038.1
    XP_011523329.1
    XP_047292366.1
    XP_047292367.1
    XP_054172660.1
    XP_054172661.1
    XP_054172662.1
    XP_054172663.1
    XP_054172664.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029437.2 RefSeqGene

      Range
      5001..144169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330450.2NP_001317379.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002546, BC037328
      Consensus CDS
      CCDS82194.1
      UniProtKB/TrEMBL
      B5BU16
      Related
      ENSP00000467213.1, ENST00000589647.5
      Conserved Domains (1) summary
      cd06617
      Location:1277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    2. NM_002758.4NP_002749.2  dual specificity mitogen-activated protein kinase kinase 6 isoform 1

      See identical proteins and their annotated locations for NP_002749.2

      Status: REVIEWED

      Source sequence(s)
      AA932919, AC002546, BC012009, DB111443
      Consensus CDS
      CCDS11686.1
      UniProtKB/Swiss-Prot
      P52564
      UniProtKB/TrEMBL
      A8K3Y2, B5BU16
      Related
      ENSP00000468348.1, ENST00000590474.7
      Conserved Domains (1) summary
      cd06617
      Location:51333
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      69414697..69553865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436411.1XP_047292367.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    2. XM_011525027.4XP_011523329.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      See identical proteins and their annotated locations for XP_011523329.1

      UniProtKB/TrEMBL
      B5BU16
      Conserved Domains (1) summary
      cd06617
      Location:1277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    3. XM_047436410.1XP_047292366.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      B5BU16
    4. XM_005257516.3XP_005257573.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      See identical proteins and their annotated locations for XP_005257573.1

      UniProtKB/TrEMBL
      B5BU16
      Conserved Domains (1) summary
      cd06617
      Location:1277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    5. XM_006721975.4XP_006722038.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      See identical proteins and their annotated locations for XP_006722038.1

      UniProtKB/TrEMBL
      B5BU16
      Conserved Domains (1) summary
      cd06617
      Location:1277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      70291653..70430810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316686.1XP_054172661.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    2. XM_054316687.1XP_054172662.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    3. XM_054316685.1XP_054172660.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      B5BU16
    4. XM_054316689.1XP_054172664.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    5. XM_054316688.1XP_054172663.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031988.1: Suppressed sequence

      Description
      NM_031988.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.