Tunar Tcl1 upstream neural differentiation associated RNA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tunarprovided by MGI
Official Full Name: Tcl1 upstream neural differentiation associated RNAprovided by MGI
Primary source: MGI:MGI:1917202
See related: Ensembl:ENSMUSG00000097929 AllianceGenome:MGI:1917202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BNLN; Tuna; pTUNAR; 2810011L19Rik
Summary: Enables ATPase binding activity. Involved in negative regulation of neuron differentiation; neuron projection morphogenesis; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including neuron fate commitment; positive regulation of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; eye; pancreas; and reproductive system. Orthologous to human TUNAR (TCL1 upstream neural differentiation-associated RNA). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 7.4), CNS E18 (RPKM 4.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 55.45 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (105303087..105350191)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (105336594..105383932)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The lincRNA TUNA plays a vital role in pluripotency and neural differentiation of ESCs and is associated with neurological function of adult vertebrates.
Title: An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment.

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General gene information

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Markers

D12Mit28 (e-PCR), detects polymorphism
- UniSTS:126838

BB314850 (e-PCR)
- UniSTS:208277

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein TUNAR

Names: beta cell and neural cell-regulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416144.1 → NP_001403073.1 protein TUNAR

Status: VALIDATED

Source sequence(s)

AC122013
NM_001416145.1 → NP_001403074.1 protein TUNAR

Status: VALIDATED

Source sequence(s)

AC122013

RNA

NR_183401.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122013

Related

ENSMUST00000180503.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

105303087..105350191

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_045047.1: Suppressed sequence

Description

NR_045047.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
NR_125773.1: Suppressed sequence

Description

NR_125773.1: This RefSeq was removed because it is now thought that this gene does encode a protein.