RNF125 ring finger protein 125 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF125provided by HGNC
Official Full Name: ring finger protein 125provided by HGNC
Primary source: HGNC:HGNC:21150
See related: Ensembl:ENSG00000101695 MIM:610432; AllianceGenome:HGNC:21150
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TNORS; TRAC1; TRAC-1
Summary: This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]
Expression: Ubiquitous expression in fat (RPKM 4.1), bone marrow (RPKM 4.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (32018825..32088144)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (32209216..32280737)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (29598788..29653182)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway.
Title: RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway.
E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression.
Title: E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression.
G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response.
Title: G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response.
this study shows that RNF125 activates Interleukin-36 receptor signaling and contributes to its turnover
Title: E3 Ubiquitin Ligase RNF125 Activates Interleukin-36 Receptor Signaling and Contributes to Its Turnover.
for the ubiquitin ligase RNF125 that, in addition to the RING domain, a C2HC Zn finger (ZnF) is crucial for activity.
Title: A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.
high RNF125 expression is related with aggressive characteristics and unfavorable prognosis of GBC patients; RNF125 promotes the invasion and metastasis of human GBCs via activating the TGF-beta1-SMAD3-ID1 signaling pathway.
Title: Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGF- β1-SMAD3-ID1 signaling pathway.
study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response
Title: The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.
we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas
Title: Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.
Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR) of ring finger protein 125 (RNF125) is a potential microRNA miR-15b targeting site.
Title: MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.
studies of the RNF125 pathway point to upregulation of RIG-I-IPS1-MDA5 and/or disruption of the PI3K-AKT and interferon signaling pathways as the putative final effectors
Title: A new overgrowth syndrome is due to mutations in RNF125.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Tenorio syndrome MedGen: C4015710 OMIM: 616260 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Cells expressing RNF125/TRAC1 downregulate the levels of HIV-1 gp120 expression	PubMed
Tat	tat	HIV-1 Tat 47-59 peptide upregulates gene expression of ring finger protein 125, E3 ubiquitin protein ligase (RNF125) in U-937 macrophages	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

D8S2279 (e-PCR)
- UniSTS:473907

GDB:314949 (e-PCR)
- UniSTS:156503

D15S1477 (e-PCR)
- UniSTS:474482

D1S1425 (e-PCR)
- UniSTS:149621

GDB:631802 (e-PCR)
- UniSTS:158429

GDB:631813 (e-PCR)
- UniSTS:158430

D15S1390 (e-PCR)
- UniSTS:474340

AB060918 (e-PCR)
- UniSTS:480228

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RIG-I signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCP-NPL4-UFD1 AAA ATPase complex	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF125

Names: T-cell RING activation protein 1; T-cell ring protein identified in activation screen; ring finger protein 125, E3 ubiquitin protein ligase

NP_060301.2

EC 2.3.2.27

XP_011524347.1

EC 2.3.2.27

XP_011524348.1

EC 2.3.2.27

XP_011524349.1

EC 2.3.2.27

XP_047293517.1

EC 2.3.2.27

XP_054174689.1

EC 2.3.2.27

XP_054174690.1

EC 2.3.2.27

XP_054174691.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042056.1 RefSeqGene

Range

5344..59738

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_017831.4 → NP_060301.2 E3 ubiquitin-protein ligase RNF125

See identical proteins and their annotated locations for NP_060301.2

Status: REVIEWED

Source sequence(s)

AC011825, AK000463, BC012021, BI666910

Consensus CDS

CCDS11902.1

UniProtKB/Swiss-Prot

Q96EQ8, Q9NX39

Related

ENSP00000217740.3, ENST00000217740.4

Conserved Domains (3) summary

cd16542
Location:35 → 76

RING-HC_RNF125; RING finger, HC subclass, found in RING finger protein 125 (RNF125)

pfam05605
Location:141 → 173

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam18574
Location:94 → 126

zf_C2HC_14; C2HC Zing finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000018.10 Reference GRCh38.p14 Primary Assembly

Range

32018825..32088144

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011526045.4 → XP_011524347.1 E3 ubiquitin-protein ligase RNF125 isoform X1

Related

ENSP00000520722.1, ENST00000718283.1

Conserved Domains (2) summary

cd00162
Location:36 → 77

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam05605
Location:141 → 173

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
XM_011526047.4 → XP_011524349.1 E3 ubiquitin-protein ligase RNF125 isoform X3

Related

ENSP00000520723.1, ENST00000718284.1

Conserved Domains (1) summary

cd00162
Location:36 → 77

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_011526046.4 → XP_011524348.1 E3 ubiquitin-protein ligase RNF125 isoform X2

Conserved Domains (2) summary

cd00162
Location:36 → 77

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam05605
Location:141 → 168

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
XM_047437561.1 → XP_047293517.1 E3 ubiquitin-protein ligase RNF125 isoform X4