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    C7orf25 chromosome 7 open reading frame 25 [ Homo sapiens (human) ]

    Gene ID: 79020, updated on 10-Oct-2024

    Summary

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    Official Symbol
    C7orf25provided by HGNC
    Official Full Name
    chromosome 7 open reading frame 25provided by HGNC
    Primary source
    HGNC:HGNC:21703
    See related
    Ensembl:ENSG00000136197 AllianceGenome:HGNC:21703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in testis (RPKM 4.7), kidney (RPKM 3.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C7orf25 in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (42909273..42912070, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (43067417..43070214, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (42948872..42951669, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr7:42845047-42845574 Neighboring gene t-complex 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18120 Neighboring gene uncharacterized LOC107986735 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:42910171-42910751 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:42915433-42916364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42917594-42918115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42923371-42924173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42927975-42928518 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42950498-42951195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42951196-42951892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25904 Neighboring gene serine-threonine kinase receptor-associated protein-like Neighboring gene proteasome 20S subunit alpha 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25905 Neighboring gene mitochondrial ribosomal protein L32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. Bommel H, et al. J Cell Biol, 2002 Nov 25. PMID 12446740, Free PMC Article
    2. MxA interacts with and is modified by the SUMOylation machinery. Brantis-de-Carvalho CE, et al. Exp Cell Res, 2015 Jan 1. PMID 25447205
    3. Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions. Kliche J, et al. Mol Syst Biol, 2023 Jul 11. PMID 37219487, Free PMC Article
    4. RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease. Bishof I, et al. J Biol Chem, 2018 Jul 13. PMID 29802200, Free PMC Article
    5. Comprehensive classification of the PIN domain-like superfamily. Matelska D, et al. Nucleic Acids Res, 2017 Jul 7. PMID 28575517, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2821, FLJ21167

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UPF0415 protein C7orf25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099858.2 → NP_001093328.2  UPF0415 protein C7orf25

      Status: VALIDATED

      Source sequence(s)
      AC010132
      Consensus CDS
      CCDS5466.1
      UniProtKB/Swiss-Prot
      A4D1V2, J3KR36, Q9BPX7, Q9H779
      UniProtKB/TrEMBL
      B4DQM3
      Related
      ENSP00000343364.4, ENST00000350427.5
      Conserved Domains (2) summary
      pfam07000
      Location:248 → 409
      DUF1308; Protein of unknown function (DUF1308)
      pfam18474
      Location:1 → 218
      DUF5614; Family of unknown function (DUF5614)

    2. NM_001363436.1 → NP_001350365.1  UPF0415 protein C7orf25

      Status: VALIDATED

      Source sequence(s)
      AK024820, BX401140, DB483522, DC303669
      Consensus CDS
      CCDS5466.1
      UniProtKB/Swiss-Prot
      A4D1V2, J3KR36, Q9BPX7, Q9H779
      UniProtKB/TrEMBL
      B4DQM3
      Related
      ENSP00000396597.1, ENST00000438029.1
      Conserved Domains (2) summary
      pfam07000
      Location:248 → 409
      DUF1308; Protein of unknown function (DUF1308)
      pfam18474
      Location:1 → 218
      DUF5614; Family of unknown function (DUF5614)

    3. NM_024054.3 → NP_076959.2  UPF0415 protein C7orf25

      See identical proteins and their annotated locations for NP_076959.2

      Status: VALIDATED

      Source sequence(s)
      AK024820, BC000769, DC303669, DC366585
      Consensus CDS
      CCDS5466.1
      UniProtKB/Swiss-Prot
      A4D1V2, J3KR36, Q9BPX7, Q9H779
      UniProtKB/TrEMBL
      B4DQM3
      Conserved Domains (2) summary
      pfam07000
      Location:248 → 409
      DUF1308; Protein of unknown function (DUF1308)
      pfam18474
      Location:1 → 218
      DUF5614; Family of unknown function (DUF5614)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      42909273..42912070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420827.1 → XP_047276783.1  UPF0415 protein C7orf25 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      43067417..43070214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358989.1 → XP_054214964.1  UPF0415 protein C7orf25 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BPX7.1 GenPept UniProtKB/Swiss-Prot:Q9BPX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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