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    plk2b polo-like kinase 2b (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 565576, updated on 4-Jan-2025

    Summary

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    Official Symbol
    plk2bprovided by ZNC
    Official Full Name
    polo-like kinase 2b (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070720-17
    See related
    Ensembl:ENSDARG00000019130 AllianceGenome:ZFIN:ZDB-GENE-070720-17
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    plk2; zgc:165644
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within sprouting angiogenesis. Predicted to be active in several cellular components, including kinetochore; microtubule cytoskeleton; and nucleus. Is expressed in endothelial cell and vasculature. Orthologous to human PLK2 (polo like kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See plk2b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (17078689..17086195)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (17042977..17050483)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D, cAMP-specific Neighboring gene si:dkey-190g11.3 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene mesoderm induction early response 1, family member 3 b Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos. Jeong K, et al. Dev Biol, 2010 Sep 1. PMID 20553902
    2. Genetic Reprogramming of Positional Memory in a Regenerating Appendage. Wang YT, et al. Curr Biol, 2019 Dec 16. PMID 31786062, Free PMC Article
    3. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Yang H, et al. Dev Biol, 2015 Aug 15. PMID 26004360, Free PMC Article
    4. Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Zhong H, et al. Mol Biosyst, 2010 Aug. PMID 20625580
    5. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Sidi S, et al. Cell, 2008 May 30. PMID 18510930, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC165644

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PLK2b
    Names
    polo-like kinase 2
    NP_001092715.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099245.1 → NP_001092715.1  serine/threonine-protein kinase PLK2b

      See identical proteins and their annotated locations for NP_001092715.1

      Status: PROVISIONAL

      Source sequence(s)
      BC146745
      UniProtKB/TrEMBL
      A6H8T5
      Related
      ENSDARP00000025106.7, ENSDART00000023206.8
      Conserved Domains (4) summary
      smart00220
      Location:54 → 306
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13117
      Location:572 → 654
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:475 → 560
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:52 → 306
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      17078689..17086195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395270.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      348523..356029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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