NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001284274.3 → NP_001271203.2 probable E3 ubiquitin-protein ligase HECTD2 isoform c
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
- Source sequence(s)
-
AC023902, AL161798
- Consensus CDS
-
CCDS60591.1
- UniProtKB/TrEMBL
- B4DIQ2, E7ERR3
- Related
- ENSP00000401023.1, ENST00000446394.5
- Conserved Domains (1) summary
-
- cd00078
Location:421 → 778
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
-
NM_001348365.2 → NP_001335294.1 probable E3 ubiquitin-protein ligase HECTD2 isoform d
Status: VALIDATED
- Description
- Transcript Variant: This variant (5) uses an alternate 5' terminal exon and lacks an alternate in-frame exon in the 5' coding region compared to variant 3. These differences result in the use of a downstream start codon compared to variant 3. The encoded isoform (d) has a shorter N-terminus compared to isoform c
- Source sequence(s)
-
AC023902, AL161798, BC036487
- UniProtKB/TrEMBL
-
B4DIQ2
- Conserved Domains (1) summary
-
- cd00078
Location:310 → 667
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
-
NM_173497.4 → NP_775768.4 probable E3 ubiquitin-protein ligase HECTD2 isoform b
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform c.
- Source sequence(s)
-
AC023902, AL161798
- Consensus CDS
-
CCDS7415.1
- Related
- ENSP00000360746.4, ENST00000371681.8
-
NM_182765.6 → NP_877497.4 probable E3 ubiquitin-protein ligase HECTD2 isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region compared to variant 3. It encodes isoform a which is shorter compared to isoform c.
- Source sequence(s)
-
AC023902, AL161798
- Consensus CDS
-
CCDS7414.1
- UniProtKB/Swiss-Prot
- Q5U5R9, Q5VZ97, Q5VZ98, Q5VZ99, Q8N1X7, Q8TCP5
- UniProtKB/TrEMBL
-
B4DIQ2
- Related
- ENSP00000298068.5, ENST00000298068.10
- Conserved Domains (1) summary
-
- cd00078
Location:417 → 774
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
RNA
-
NR_104291.3 RNA Sequence
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) has multiple difference compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC023902, AL161798
-
NR_145526.2 RNA Sequence
Status: VALIDATED
- Description
- Transcript Variant: This variant (6) lacks an alternate internal exon and uses alternate splice sites in two internal exon compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC023902, AL161798