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    ERJ5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850602, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ERJ5
    Primary source
    SGD:S000001937
    Locus tag
    YFR041C
    See related
    AllianceGenome:SGD:S000001937; FungiDB:YFR041C; VEuPathDB:YFR041C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein folding. Located in endoplasmic reticulum. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (237368..238255, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Osw7p Neighboring gene Sap155p Neighboring gene Keg1p Neighboring gene Irc6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum. Carla Famá M, et al. Biochim Biophys Acta, 2007 Feb. PMID 17157937, Free PMC Article
    2. The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity. Sluder IT, et al. PLoS Genet, 2018 Nov. PMID 30452489, Free PMC Article
    3. Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast. Medkour Y, et al. Oncotarget, 2019 Oct 8. PMID 31645900, Free PMC Article
    4. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. Murley A, et al. J Cell Biol, 2015 May 25. PMID 25987606, Free PMC Article
    5. Systems analysis of the genetic interaction network of yeast molecular chaperones. Rizzolo K, et al. Mol Omics, 2018 Apr 16. PMID 29659649

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response, indicating that ERJ5 is required for maintenance of an optimal folding environment in the yeast endoplasmic reticulum.
      Title: The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Erj5p
    NP_116699.3
    • Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      237368..238255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180006.3 → NP_116699.3  TPA: Erj5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116699.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTS4, P43613
      UniProtKB/TrEMBL
      A7A281, B3LUQ2, B5VI66, C7GYE5, C8Z7X6, G2WDI2, N1P4R8
      Conserved Domains (2) summary
      COG2214
      Location:41 → 271
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:44 → 105
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43613.1

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