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    YGK3 serine/threonine protein kinase YGK3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853992, updated on 1-Aug-2024

    Summary

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    Gene symbol
    YGK3
    Gene description
    serine/threonine protein kinase YGK3
    Primary source
    FungiDB:YOL128C
    Locus tag
    YOL128C
    See related
    SGD:S000005488; AllianceGenome:SGD:S000005488; VEuPathDB:YOL128C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to heat; cellular response to salt stress; and protein phosphorylation. Predicted to be part of mediator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YGK3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (78352..79479, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mg(2+) transporter ALR1 Neighboring gene Vps68p Neighboring gene ribosomal 60S subunit protein L25 Neighboring gene malate dehydrogenase MDH2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In silico evidence for functional specialization after genome duplication in yeast. Turunen O, et al. FEMS Yeast Res, 2009 Feb. PMID 19133069, Free PMC Article
    2. Phosphorylation of the Gα protein Gpa2 promotes protein kinase A signaling in yeast. Huang S, et al. J Biol Chem, 2019 Dec 6. PMID 31690628, Free PMC Article
    3. Sequence analysis of a 13.4 kbp fragment from the left arm of chromosome XV reveals a malate dehydrogenase gene, a putative Ser/Thr protein kinase, the ribosomal L25 gene and four new open reading frames. Casamayor A, et al. Yeast, 1996 Sep. PMID 8896265
    4. The Saccharomyces cerevisiae GSK-3 beta homologs. Kassir Y, et al. Curr Drug Targets, 2006 Nov. PMID 17100585
    5. The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms. Tiedje C, et al. Mol Biol Cell, 2008 Jul. PMID 18417612, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase YGK3
    NP_014513.1
    • Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      78352..79479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183382.1 → NP_014513.1  TPA: serine/threonine protein kinase YGK3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014513.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1U0, Q12222
      UniProtKB/TrEMBL
      A6ZN83, C7GV04, N1NVV3
      Conserved Domains (2) summary
      smart00220
      Location:44 → 329
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14137
      Location:35 → 332
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12222.1

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