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    RTC1 Rtc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853982, updated on 1-Aug-2024

    Summary

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    Gene symbol
    RTC1
    Gene description
    Rtc1p
    Primary source
    FungiDB:YOL138C
    Locus tag
    YOL138C
    See related
    SGD:S000005498; AllianceGenome:SGD:S000005498; VEuPathDB:YOL138C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEA2
    Summary
    Predicted to enable metal ion binding activity. Involved in positive regulation of TORC1 signaling. Is extrinsic component of fungal-type vacuolar membrane. Part of Seh1-associated complex. Orthologous to human WDR24 (WD repeat domain 24). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RTC1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (61325..65350, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene acetylornithine transaminase Neighboring gene translation initiation factor eIF4E Neighboring gene Bsc6p Neighboring gene 6-phosphofructo-2-kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway. Zhang Y, et al. Proc Natl Acad Sci U S A, 2021 Sep 14. PMID 34507998, Free PMC Article
    2. Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae. Polleys EJ, et al. G3 (Bethesda), 2015 May 4. PMID 25943524, Free PMC Article
    3. Distinct temporal requirements for autophagy and the proteasome in yeast meiosis. Wen FP, et al. Autophagy, 2016. PMID 27050457, Free PMC Article
    4. Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Panchaud N, et al. Sci Signal, 2013 May 28. PMID 23716719
    5. A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Dokudovskaya S, et al. Mol Cell Proteomics, 2011 Jun. PMID 21454883, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rtc1p
    NP_014503.2
    • Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      61325..65350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183392.2 → NP_014503.2  TPA: Rtc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014503.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1T1, Q08281, Q92271
      UniProtKB/TrEMBL
      G2WMA0
      Conserved Domains (3) summary
      sd00039
      Location:213 → 256
      7WD40; WD40 repeat [structural motif]
      cd16693
      Location:1292 → 1339
      mRING-H2-C3H3C2_WDR24; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 24 (WDR24) and similar proteins
      cl29593
      Location:202 → 396
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08281.2

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