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    GIP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855967, updated on 11-Sep-2024

    Summary

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    Official Symbol
    GIP3
    Primary source
    SGD:S000006058
    Locus tag
    YPL137C
    See related
    AllianceGenome:SGD:S000006058; FungiDB:YPL137C; VEuPathDB:YPL137C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein phosphatase 1 binding activity and protein phosphatase regulator activity. Involved in chromosome segregation and regulation of phosphoprotein phosphatase activity. Located in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (292817..296647, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ume1p Neighboring gene Spp1p Neighboring gene iron-binding protein ISU1 Neighboring gene mitochondrial 2-oxodicarboxylate carrier

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Pinsky BA, et al. Mol Cell Biol, 2006 Apr. PMID 16537909, Free PMC Article
    2. A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Stevenson LF, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274415, Free PMC Article
    3. Novel interactions of Saccharomyces cerevisiae type 1 protein phosphatase identified by single-step affinity purification and mass spectrometry. Walsh EP, et al. Biochemistry, 2002 Feb 19. PMID 11841235
    4. Identifying protein kinase-specific effectors of the osmostress response in yeast. Romanov N, et al. Sci Signal, 2017 Mar 7. PMID 28270554, Free PMC Article
    5. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors found 245 genes required for the normal growth of the Glc7 mutant.
      Title: Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    protein phosphatase regulator GIP3
    NP_015188.1
    • Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      292817..296647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183951.1 → NP_015188.1  TPA: protein phosphatase regulator GIP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015188.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3N1, Q03016
      UniProtKB/TrEMBL
      A6ZWB6, B3LKT9, C7GJ89
      Conserved Domains (1) summary
      PRK04132
      Location:842 → 1004
      PRK04132; replication factor C small subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03016.1

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