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    SAA3P serum amyloid A3, pseudogene [ Homo sapiens (human) ]

    Gene ID: 6290, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SAA3Pprovided by HGNC
    Official Full Name
    serum amyloid A3, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:10515
    See related
    Ensembl:ENSG00000290741 AllianceGenome:HGNC:10515
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAA3
    Summary
    Predicted to enable Toll-like receptor 4 binding activity and chemoattractant activity. Predicted to be involved in response to stilbenoid. Predicted to act upstream of or within several processes, including I-kappaB phosphorylation; cell chemotaxis; and cellular response to interleukin-1. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See SAA3P in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18112472..18116132, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18208017..18211675, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18134019..18137679, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene serum amyloid A like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4491 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 5 Neighboring gene MAS related GPR family member X3 Neighboring gene MAS related GPR family member X12, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Induction of human mammary-associated serum amyloid A3 expression by prolactin or lipopolysaccharide. Larson MA, et al. Biochem Biophys Res Commun, 2003 Feb 21. PMID 12589816
    2. The human serum amyloid A (SAA)-encoding gene GSAA1: nucleotide sequence and possible autocrine-collagenase-inducer function. Sack GH Jr, et al. Gene, 1989 Dec 14. PMID 2558975
    3. Nonexpression of the human serum amyloid A three (SAA3) gene. Kluve-Beckerman B, et al. DNA Cell Biol, 1991 Nov. PMID 1755958
    4. Localization of four human serum amyloid A (SAA) protein superfamily genes to chromosome 11p: characterization of a fifth SAA-related gene sequence. Sellar GC, et al. Genomics, 1993 Jun. PMID 8325654
    5. A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. Hansen MT, et al. Oncogene, 2015 Jan 22. PMID 24469032

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies indicate that long non-coding RNA MALAT1 regulates glucose-induced up-regulation of inflammatory mediators tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) through activation of serum amyloid antigen 3 (SAA3).
      Title: Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells.
    2. serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.
      Title: A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026576.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090099
      Related
      ENST00000534768.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      18112472..18116132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      18208017..18211675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_002634.3: Suppressed sequence

      Description
      NG_002634.3: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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