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    MSI1 Msi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852494, updated on 7-Jul-2024

    Summary

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    Gene symbol
    MSI1
    Gene description
    Msi1p
    Primary source
    FungiDB:YBR195C
    Locus tag
    YBR195C
    See related
    SGD:S000000399; AllianceGenome:SGD:S000000399; VEuPathDB:YBR195C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CAC3
    Summary
    Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in cytoplasm and nucleus. Part of CAF-1 complex. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MSI1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (610614..611882, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Med8p Neighboring gene Aim4p Neighboring gene glucose-6-phosphate isomerase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif. Démolis N, et al. Yeast, 1993 Jun. PMID 8346681
    2. Host genes that affect the target-site distribution of the yeast retrotransposon Ty1. Huang H, et al. Genetics, 1999 Apr. PMID 10101165, Free PMC Article
    3. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. Mattiroli F, et al. Sci Rep, 2017 Apr 18. PMID 28418026, Free PMC Article
    4. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Kaufman PD, et al. Genes Dev, 1997 Feb 1. PMID 9030687
    5. MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae. Ruggieri R, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2554329, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rho5p is a target of Msi1p/Npr1p regulation and the regulatory circuit involving phosphorylation and ubiquitination.
      Title: Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination.
    2. Over-expression of YAK1 decreased the growth rate, but only in the presence of a functional MSI1 gene.
      Title: Mutual interdependence of MSI1 (CAC3) and YAK1 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Msi1p
    NP_009754.1
    • Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      610614..611882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178543.1 → NP_009754.1  TPA: Msi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQI9, P13712
      UniProtKB/TrEMBL
      A0A8H4F9F9, B5VEE4, C7GKF4, D3UET9, G2W9J6, N1P6Y4
      Conserved Domains (3) summary
      sd00039
      Location:133 → 173
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:21 → 88
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:141 → 413
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13712.1

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