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    TGL3 bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855361, updated on 17-May-2024

    Summary

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    Gene symbol
    TGL3
    Gene description
    bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase
    Primary source
    FungiDB:YMR313C
    Locus tag
    YMR313C
    See related
    SGD:S000004930; AllianceGenome:SGD:S000004930; VEuPathDB:YMR313C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lysophosphatidylethanolamine acyltransferase activity and triglyceride lipase activity. Involved in cell budding and triglyceride catabolic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TGL3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (899379..901307, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Glc8p Neighboring gene Elongator subunit ELP6 Neighboring gene proteasome core particle subunit alpha 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modifications of the C terminus affect functionality and stability of yeast triacylglycerol lipase Tgl3p. Koch B, et al. J Biol Chem, 2014 Jul 11. PMID 24847060, Free PMC Article
    2. Regulation of the yeast triacylglycerol lipase TGl3p by formation of nonpolar lipids. Schmidt C, et al. J Biol Chem, 2013 Jul 5. PMID 23673660, Free PMC Article
    3. YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. Athenstaedt K, et al. J Biol Chem, 2003 Jun 27. PMID 12682047
    4. Metabolic engineering of lipid pathways in Saccharomyces cerevisiae and staged bioprocess for enhanced lipid production and cellular physiology. Peng H, et al. J Ind Microbiol Biotechnol, 2018 Aug. PMID 29804179
    5. Lipids containing medium-chain fatty acids are specific to post-whole genome duplication Saccharomycotina yeasts. Froissard M, et al. BMC Evol Biol, 2015 May 28. PMID 26018144, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the topology of Tgl3p is important for its function and strongly dependent on the membrane environment.
      Title: Modifications of the C terminus affect functionality and stability of yeast triacylglycerol lipase Tgl3p.
    2. the activity of Tgl3p is restricted to lipid droplets, whereas the endoplasmic reticulum may serve as a parking lot for this enzyme.
      Title: Regulation of the yeast triacylglycerol lipase TGl3p by formation of nonpolar lipids.
    3. Results demonstrate that yeast Tgl3p and Tgl5p play a dual role in lipid metabolism contributing to both anabolic and catabolic processes.
      Title: Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidylethanolamine acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triglyceride lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triglyceride lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell budding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell budding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet HDA PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase
    NP_014044.1
    • Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      899379..901307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182824.1 → NP_014044.1  TPA: bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0E0, P40308
      UniProtKB/TrEMBL
      A0A8H4F888, A6ZN30, B3LMK1, B5VQ79, C7GPV0, C8ZFI4, D3YHF6, G2WL22, N1NXU7
      Conserved Domains (1) summary
      cd07229
      Location:130 → 640
      Pat_TGL3_like; Triacylglycerol lipase 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40308.2

    Gene LinkOut

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