U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FOL3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855140, updated on 11-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FOL3
    Primary source
    SGD:S000004719
    Locus tag
    YMR113W
    See related
    AllianceGenome:SGD:S000004719; FungiDB:YMR113W; VEuPathDB:YMR113W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dihydrofolate synthase activity. Involved in folic acid-containing compound biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (494999..496282)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Euc1p Neighboring gene Med11p Neighboring gene putative peptide hydrolase Neighboring gene Mgr3p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation of the Pneumocystis carinii dihydrofolate synthase gene and functional complementation in Saccharomyces cerevisiae. Hauser PM, et al. FEMS Microbiol Lett, 2006 Mar. PMID 16499613
    2. Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae. Bayly AM, et al. FEMS Microbiol Lett, 2001 Nov 13. PMID 11731153
    3. Nutritional control of epigenetic processes in yeast and human cells. Sadhu MJ, et al. Genetics, 2013 Nov. PMID 23979574, Free PMC Article
    4. A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Salcedo E, et al. Mol Biochem Parasitol, 2001 Feb. PMID 11223131
    5. Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. Cherest H, et al. J Biol Chem, 2000 May 12. PMID 10799479

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrofolate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrofolate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrofolate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dihydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dihydrofolate synthase
    NP_013831.1
    • Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      494999..496282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182613.1 → NP_013831.1  TPA: dihydrofolate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013831.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZT6, Q12676
      UniProtKB/TrEMBL
      A6ZMH0, B3LM04, C7GW96, C8ZEW6, G2WKG3, N1NXC5
      Conserved Domains (1) summary
      COG0285
      Location:3 → 427
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12676.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools