ilvbl ilvB (bacterial acetolactate synthase)-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ilvblprovided by ZNC
Official Full Name: ilvB (bacterial acetolactate synthase)-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1623
See related: Ensembl:ENSDARG00000017126 AllianceGenome:ZFIN:ZDB-GENE-040426-1623
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66376; zgc:85697
Summary: Predicted to enable acetolactate synthase activity and flavin adenine dinucleotide binding activity. Acts upstream of or within embryonic cranial skeleton morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of acetolactate synthase complex. Orthologous to human ILVBL (ilvB acetolactate synthase like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (44768952..44791891)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (44775517..44798437)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetolactate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde-lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid alpha-oxidation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetolactate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-hydroxyacyl-CoA lyase 2

Names: acetolactate synthase-like protein; ilvB-like protein

NP_956960.2

EC 4.1.2.-

XP_021323297.1

EC 4.1.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200666.2 → NP_956960.2 2-hydroxyacyl-CoA lyase 2

See identical proteins and their annotated locations for NP_956960.2

Status: PROVISIONAL

Source sequence(s)

BC068362

UniProtKB/Swiss-Prot

Q6NV04

Related

ENSDARP00000004404.7, ENSDART00000016271.9

Conserved Domains (4) summary

cd07035
Location:45 → 199

TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins

COG0028
Location:41 → 609

IlvB; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]

cd02004
Location:436 → 609

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...

pfam00205
Location:262 → 394

TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

44768952..44791891

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467622.2 → XP_021323297.1 2-hydroxyacyl-CoA lyase 2 isoform X1

UniProtKB/TrEMBL

A0A8M9P109

Conserved Domains (1) summary

COG0028
Location:71 → 639

IlvB; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]