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    ppp2r5d protein phosphatase 2, regulatory subunit B', delta [ Danio rerio (zebrafish) ]

    Gene ID: 406610, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp2r5dprovided by ZNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B', deltaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2568
    See related
    Ensembl:ENSDARG00000014428 AllianceGenome:ZFIN:ZDB-GENE-040426-2568
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73160; zgc:77529
    Summary
    Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within signal transduction. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppp2r5d in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (4232568..4303614, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (4104072..4175118, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene delta-like 2 homolog (Drosophila) Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene male-enhanced antigen 1 Neighboring gene zinc finger protein 318 Neighboring gene si:dkeyp-121d4.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
    2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213318.1 → NP_998483.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

      See identical proteins and their annotated locations for NP_998483.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067382
      UniProtKB/TrEMBL
      Q6NWX4
      Related
      ENSDARP00000113159.2, ENSDART00000136262.3
      Conserved Domains (2) summary
      PLN00122
      Location:405 → 507
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:97 → 500
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      4232568..4303614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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