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    cdon cell adhesion associated, oncogene regulated [ Danio rerio (zebrafish) ]

    Gene ID: 280652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdonprovided by ZNC
    Official Full Name
    cell adhesion associated, oncogene regulatedprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021115-4
    See related
    Ensembl:ENSDARG00000061328 AllianceGenome:ZFIN:ZDB-GENE-021115-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb507; wu:fa10c03; wu:fb94b11; zgc:158240
    Summary
    Acts upstream of or within negative regulation of smoothened signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural plate; and neural tube. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdon in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44053013..44129028, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44059154..44135574, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene bcl9 like Neighboring gene V-set and immunoglobulin domain-containing protein 10-like 2 Neighboring gene uncharacterized LOC137488334 Neighboring gene si:ch211-151h10.2 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 179

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish. Lencer E, et al. Development, 2023 Jul 15. PMID 37390228, Free PMC Article
    2. Cdon promotes neural crest migration by regulating N-cadherin localization. Powell DR, et al. Dev Biol, 2015 Nov 15. PMID 26256768, Free PMC Article
    3. Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Cardozo MJ, et al. Nat Commun, 2014 Jul 8. PMID 25001599, Free PMC Article
    4. Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Bergeron SA, et al. Development, 2011 Jan. PMID 21115611, Free PMC Article
    5. Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Wang X, et al. Biol Open, 2013. PMID 24244857, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.
      Title: Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.
    2. Cdon is required to localize N-cadherin to the cell membrane in migratory neural crest cells for directed migration.
      Title: Cdon promotes neural crest migration by regulating N-cadherin localization.
    3. In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog protein, thereby limiting its dispersion.
      Title: Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell adhesion molecule-related/down-regulated by oncogenes

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081628.1 → NP_001075097.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

      See identical proteins and their annotated locations for NP_001075097.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133076
      UniProtKB/TrEMBL
      A2RUW8, Q1L8D0
      Related
      ENSDARP00000081773.4, ENSDART00000087339.6
      Conserved Domains (5) summary
      smart00408
      Location:239 → 294
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:230 → 310
      IG_like; Immunoglobulin like
      cd00063
      Location:594 → 685
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:315 → 399
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:317 → 399
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44053013..44129028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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