parp3 poly (ADP-ribose) polymerase family, member 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: parp3provided by ZNC
Official Full Name: poly (ADP-ribose) polymerase family, member 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7435
See related: Ensembl:ENSDARG00000003961 AllianceGenome:ZFIN:ZDB-GENE-030131-7435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Adprtl3; fj17c06; zgc:66157; wu:fj17c06
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Acts upstream of or within ectodermal placode development and regulation of neural crest formation. Predicted to be located in chromosome and nucleus. Predicted to be active in nucleolus and site of double-strand break. Is expressed in axis and notochord. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (42038358..42049350, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (42040822..42051814, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parp3 is crucial in the early stages of zebrafish development, possibly by exerting its transcriptional regulatory functions as early as during the specification of the neural plate border
Title: A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables pentosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ectodermal placode development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP3

Names: ADP-ribosyltransferase (NAD+; poly (ADP-ribose polymerase)-like 3

NP_956795.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200501.1 → NP_956795.1 protein mono-ADP-ribosyltransferase PARP3

See identical proteins and their annotated locations for NP_956795.1

Status: PROVISIONAL

Source sequence(s)

BC055518

UniProtKB/TrEMBL

Q7SXN8, Q7ZVB0

Related

ENSDARP00000026625.7, ENSDART00000022949.8

Conserved Domains (3) summary

cd08002
Location:59 → 157

WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins

cd01437
Location:183 → 527

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:323 → 528

PARP; Poly(ADP-ribose) polymerase catalytic domain