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    ugp2b UDP-glucose pyrophosphorylase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 334420, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ugp2bprovided by ZNC
    Official Full Name
    UDP-glucose pyrophosphorylase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6352
    See related
    Ensembl:ENSDARG00000008200 AllianceGenome:ZFIN:ZDB-GENE-030131-6352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Ugp2; fi53h10; zgc:85662; wu:fi53h10
    Summary
    Predicted to enable UTP:glucose-1-phosphate uridylyltransferase activity. Involved in larval locomotory behavior. Predicted to be active in cytoplasm. Is expressed in epidermis; notochord; polster; pronephric duct; and ventral mesoderm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ugp2b in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (24445545..24470589)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (24427144..24452188)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene orthodenticle homeobox 1 Neighboring gene WD repeat containing planar cell polarity effector Neighboring gene malate dehydrogenase 1Ab, NAD (soluble) Neighboring gene pellino E3 ubiquitin protein ligase 1b Neighboring gene uncharacterized LOC137488099 Neighboring gene ATP-binding cassette, sub-family H, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases. Perenthaler E, et al. Acta Neuropathol, 2020 Mar. PMID 31820119, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-alpha-D-glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glucose pyrophosphorylase 2b
    Names
    UDP-glucose pyrophosphorylase 2
    NP_001303819.1
    NP_997894.2
    XP_005158553.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316890.1 → NP_001303819.1  UDP-glucose pyrophosphorylase 2b isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CR352220, EH433688
      UniProtKB/TrEMBL
      A0A8M1P748
      Related
      ENSDARP00000115076.1, ENSDART00000139963.3
      Conserved Domains (1) summary
      pfam01704
      Location:103 → 519
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    2. NM_212729.2 → NP_997894.2  UDP-glucose pyrophosphorylase 2b isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and distinct 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      CR352220, DT081919
      UniProtKB/TrEMBL
      A0A8M1PLK9, F1QDY2
      Related
      ENSDARP00000123568.1, ENSDART00000140467.3
      Conserved Domains (1) summary
      pfam01704
      Location:55 → 471
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      24445545..24470589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158496.5 → XP_005158553.1  UDP-glucose pyrophosphorylase 2b isoform X1

      UniProtKB/TrEMBL
      A0A0R4IBN4, A0A8M2B4X0
      Related
      ENSDARP00000129923.1, ENSDART00000163221.3
      Conserved Domains (1) summary
      pfam01704
      Location:59 → 475
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394990.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1749..26793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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