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    lap3 leucine aminopeptidase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 562854, updated on 2-Nov-2024

    Summary

    Official Symbol
    lap3provided by ZNC
    Official Full Name
    leucine aminopeptidase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060719-1
    See related
    Ensembl:ENSDARG00000061981 AllianceGenome:ZFIN:ZDB-GENE-060719-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7150907
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; head; immature eye; midbrain; and musculature system. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See lap3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (19418380..19431510, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (18725443..18738573, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene tyrosinase-related protein 1b Neighboring gene RNA binding motif protein 47 Neighboring gene clock circadian regulator b Neighboring gene KIT proto-oncogene, receptor tyrosine kinase b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytosol aminopeptidase
    NP_001108319.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114847.1NP_001108319.1  cytosol aminopeptidase

      Status: PROVISIONAL

      Source sequence(s)
      BX901913
      UniProtKB/TrEMBL
      A0A8M1NGB5, A2BIC6
      Related
      ENSDARP00000083458.5, ENSDART00000089025.6
      Conserved Domains (2) summary
      PRK00913
      Location:34511
      PRK00913; multifunctional aminopeptidase A; Provisional
      cd00433
      Location:32510
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      19418380..19431510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)