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    cul4b cullin 4B [ Danio rerio (zebrafish) ]

    Gene ID: 560313, updated on 2-Nov-2024

    Summary

    Official Symbol
    cul4bprovided by ZNC
    Official Full Name
    cullin 4Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041008-208
    See related
    Ensembl:ENSDARG00000060510 AllianceGenome:ZFIN:ZDB-GENE-041008-208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7140950; im:7150765
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in DNA damage response and protein ubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of Cul4B-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See cul4b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33486151..33505709)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (33145837..33165395)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit beta 4 Neighboring gene lysosomal-associated membrane protein 2 Neighboring gene MCTS1 re-initiation and release factor Neighboring gene C1GALT1-specific chaperone 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul4B-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122844.1NP_001116316.1  cullin-4B

      Status: PROVISIONAL

      Source sequence(s)
      BX004980
      UniProtKB/TrEMBL
      A0A8M1NIA7, F8W428
      Related
      ENSDARP00000124267.1, ENSDART00000149254.3
      Conserved Domains (3) summary
      smart00182
      Location:547687
      CULLIN; Cullin
      smart00884
      Location:793858
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:169764
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      33486151..33505709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)