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    usp7 ubiquitin specific peptidase 7 (herpes virus-associated) [ Danio rerio (zebrafish) ]

    Gene ID: 553758, updated on 4-Jan-2025

    Summary

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    Official Symbol
    usp7provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 7 (herpes virus-associated)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3656
    See related
    Ensembl:ENSDARG00000073710 AllianceGenome:ZFIN:ZDB-GENE-030131-3656
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc48f04; wu:fc48f04
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See usp7 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (27606717..27640823)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (27475865..27509981)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490601 Neighboring gene HUWE1 associated protein modifying stress responses a Neighboring gene si:ch211-157c3.4 Neighboring gene pentraxin 4, long Neighboring gene chloride channel 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Loontiens S, et al. Leukemia, 2020 Dec. PMID 32591643, Free PMC Article
    2. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
    3. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
    4. Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Zhou Z, et al. Dev Cell, 2015 Jul 6. PMID 26120032, Free PMC Article
    5. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 7
    XP_005164014.1
    XP_009297739.3
    XP_009297740.3
    XP_009297741.1
    XP_021329546.1
    XP_691215.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      27606717..27640823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163957.4 → XP_005164014.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BB86, A0A8M3B8A7, F1QUS9
      Related
      ENSDARP00000002502.7, ENSDART00000024453.10
      Conserved Domains (5) summary
      COG5077
      Location:57 → 1108
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:213 → 531
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:68 → 203
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:628 → 873
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:883 → 1094
      USP7_C2; Ubiquitin-specific protease C-terminal

    2. XM_686123.10 → XP_691215.4  ubiquitin carboxyl-terminal hydrolase 7 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AQW7, A0A8N7UV92, I3ISS5
      Related
      ENSDARP00000125968.1, ENSDART00000150953.3
      Conserved Domains (5) summary
      COG5077
      Location:57 → 1101
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:213 → 524
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:68 → 203
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:621 → 866
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:876 → 1087
      USP7_C2; Ubiquitin-specific protease C-terminal

    3. XM_021473871.2 → XP_021329546.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X6

      UniProtKB/TrEMBL
      A0A8M3B8A7, A0A8M9Q474
      Conserved Domains (1) summary
      cl02553
      Location:33 → 1084
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    4. XM_009299466.4 → XP_009297741.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B0Y8, A0A8M3B8A7
      Conserved Domains (5) summary
      COG5077
      Location:43 → 1094
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:199 → 517
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:54 → 189
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:614 → 859
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:869 → 1080
      USP7_C2; Ubiquitin-specific protease C-terminal

    5. XM_009299464.4 → XP_009297739.3  ubiquitin carboxyl-terminal hydrolase 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B8A7

    6. XM_009299465.4 → XP_009297740.3  ubiquitin carboxyl-terminal hydrolase 7 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AQW7
    Nucleotide Protein Strain
    Heading Accession and Version

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