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    eif4g2a eukaryotic translation initiation factor 4, gamma 2a [ Danio rerio (zebrafish) ]

    Gene ID: 323453, updated on 2-Nov-2024

    Summary

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    Official Symbol
    eif4g2aprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2173
    See related
    Ensembl:ENSDARG00000020377 AllianceGenome:ZFIN:ZDB-GENE-030131-2173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NAT1A; im:7148615; wu:fb81f07; wu:fb82b06; wu:fb98h08
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Acts upstream of or within mesoderm development. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in deep blastomere and superficial blastomere. Orthologous to human EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See eif4g2a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (66634233..66654033)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (66410585..66430385)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18b Neighboring gene transmembrane protein 176l.3b Neighboring gene inositol 1,4,5-triphosphate receptor associated 2-like Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The eIF4G-homolog p97 can activate translation independent of caspase cleavage. Nousch M, et al. RNA, 2007 Mar. PMID 17237356, Free PMC Article
    2. Transcription organizes euchromatin via microphase separation. Hilbert L, et al. Nat Commun, 2021 Mar 1. PMID 33649325, Free PMC Article
    3. Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos. Stapel LC, et al. Development, 2016 Feb 1. PMID 26700682
    4. Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). Takahashi K, et al. Genomics, 2005 Mar. PMID 15718103
    5. Reduced expression of the Nodal co-receptor Oep causes loss of mesendodermal competence in zebrafish. Vopalensky P, et al. Development, 2018 Mar 6. PMID 29440298

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC192940

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 2a
    Names
    eIF4G-related protein NAT1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014289.2 → NP_001014311.1  eukaryotic translation initiation factor 4 gamma 2a

      See identical proteins and their annotated locations for NP_001014311.1

      Status: VALIDATED

      Source sequence(s)
      AB096100, BI673329, EB778139
      UniProtKB/TrEMBL
      Q5KTT7
      Related
      ENSDARP00000017878.7, ENSDART00000027616.9
      Conserved Domains (4) summary
      cd11559
      Location:713 → 860
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:529 → 642
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:73 → 303
      MIF4G; MIF4G domain
      pfam11235
      Location:376 → 523
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      66634233..66654033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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