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    TMA17 Tma17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851448, updated on 29-Jun-2024

    Summary

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    Gene symbol
    TMA17
    Gene description
    Tma17p
    Primary source
    FungiDB:YDL110C
    Locus tag
    YDL110C
    See related
    SGD:S000002268; AllianceGenome:SGD:S000002268; VEuPathDB:YDL110C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ADC17
    Summary
    Enables protein-macromolecule adaptor activity. Involved in fatty acid biosynthetic process and proteasome regulatory particle assembly. Located in cytoplasm and nucleus. Part of fatty acid synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TMA17 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (264512..264964, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA (guanosine(18)-2'-O)-methyltransferase Neighboring gene exosome non-catalytic core subunit RRP42 Neighboring gene putative lipase Neighboring gene TFIIH complex serine/threonine-protein kinase subunit KIN28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Singh K, et al. Cell, 2020 Mar 19. PMID 32160528
    2. Actin remodelling controls proteasome homeostasis upon stress. Williams TD, et al. Nat Cell Biol, 2022 Jul. PMID 35739319, Free PMC Article
    3. Proteomic analysis revealed the roles of YRR1 deletion in enhancing the vanillin resistance of Saccharomyces cerevisiae. Cao W, et al. Microb Cell Fact, 2021 Jul 23. PMID 34301255, Free PMC Article
    4. An inducible chaperone adapts proteasome assembly to stress. Hanssum A, et al. Mol Cell, 2014 Aug 21. PMID 25042801, Free PMC Article
    5. Proteomic analysis of recombinant Saccharomyces cerevisiae upon iron deficiency induced via human H-ferritin production. Seo HY, et al. J Microbiol Biotechnol, 2008 Aug. PMID 18756096

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular function regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome regulatory particle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome regulatory particle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome regulatory particle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of fatty acid synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tma17p
    NP_010173.1
    • Regulatory gamma subunit of fatty acid synthase (FAS); ATPase dedicated chaperone that adapts proteasome assembly to stress; induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      264512..264964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180169.1 → NP_010173.1  TPA: Tma17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRP0, Q12513
      UniProtKB/TrEMBL
      A0A6A5PY03, A6ZXL9, B3LH01, C7GJK6, C8Z6J4, G2WC52, N1P7L9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12513.1

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