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    chek2 checkpoint kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 336998, updated on 14-Nov-2024

    Summary

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    Official Symbol
    chek2provided by ZNC
    Official Full Name
    checkpoint kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8942
    See related
    Ensembl:ENSDARG00000025820 AllianceGenome:ZFIN:ZDB-GENE-030131-8942
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa66f08; zgc:55865; wu:fa66f08
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within DNA damage response. Predicted to be active in cytoplasm and nucleus. Is expressed in eye; head; optic tectum; and proliferative region. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See chek2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (10055991..10082226, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (9551342..9577601, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490761 Neighboring gene solute carrier family 2 member 11b Neighboring gene glutathione S-transferase theta 2 Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone Neighboring gene uncharacterized LOC108190050

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CHK2 kinase--a busy messenger. Bartek J, et al. Nat Rev Mol Cell Biol, 2001 Dec. PMID 11733767
    2. Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition. Bertho S, et al. Development, 2021 Apr 1. PMID 33722898, Free PMC Article
    3. Hdac1-deficiency affects the cell cycle axis Cdc25-Cdk1 causing impaired G2/M phase progression and reduced cardiomyocyte proliferation in zebrafish. Boos A, et al. Biochem Biophys Res Commun, 2023 Jul 12. PMID 37149988
    4. Macrophage activation drives ovarian failure and masculinization in zebrafish. Bravo P, et al. Sci Adv, 2023 Nov 24. PMID 37992158, Free PMC Article
    5. Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53. Yamaguchi M, et al. Development, 2008 Apr. PMID 18287205

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Chk2
    NP_956339.1
    XP_005165087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200045.1 → NP_956339.1  serine/threonine-protein kinase Chk2

      See identical proteins and their annotated locations for NP_956339.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044519
      UniProtKB/TrEMBL
      Q803E2
      Related
      ENSDARP00000036490.6, ENSDART00000036421.7
      Conserved Domains (3) summary
      smart00220
      Location:193 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:72 → 174
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:186 → 456
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      10055991..10082226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165030.5 → XP_005165087.1  serine/threonine-protein kinase Chk2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC68
      Conserved Domains (4) summary
      smart00220
      Location:193 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1716
      Location:73 → 173
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:72 → 174
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:186 → 456
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394566.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      195199..223751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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