cbwd COBW domain containing [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cbwdprovided by ZNC
Official Full Name: COBW domain containingprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2388
See related: Ensembl:ENSDARG00000004318 AllianceGenome:ZFIN:ZDB-GENE-040426-2388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zng1; fb76b04; fc73a04; zgc:77617; wu:fb76b04; wu:fc73a04
Summary: Enables GTPase activity and zinc chaperone activity. Involved in intracellular zinc ion homeostasis. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to several human genes including ZNG1C (Zn regulated GTPase metalloprotein activator 1C); ZNG1E (Zn regulated GTPase metalloprotein activator 1E); and ZNG1F (Zn regulated GTPase metalloprotein activator 1F). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (30425675..30450072)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (30416496..30440840)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables zinc chaperone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular zinc ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc-regulated GTPase metalloprotein activator 1

Names: COBW domain-containing protein 1; cobalamin synthase W domain-containing protein 1

NP_998418.1

EC 3.6.5.-

XP_068079016.1

EC 3.6.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213253.1 → NP_998418.1 zinc-regulated GTPase metalloprotein activator 1

See identical proteins and their annotated locations for NP_998418.1

Status: PROVISIONAL

Source sequence(s)

BC065429

UniProtKB/Swiss-Prot

B0R0B1, Q6P0V9

Related

ENSDARP00000009109.7, ENSDART00000012132.8

Conserved Domains (3) summary

COG0523
Location:24 → 355

YejR; GTPase, G3E family [General function prediction only]

pfam07683
Location:258 → 355

CobW_C; Cobalamin synthesis protein cobW C-terminal domain

cl21455
Location:25 → 189

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases