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    pds5a PDS5 cohesin associated factor A [ Danio rerio (zebrafish) ]

    Gene ID: 393967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pds5aprovided by ZNC
    Official Full Name
    PDS5 cohesin associated factor Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1612
    See related
    Ensembl:ENSDARG00000055022 AllianceGenome:ZFIN:ZDB-GENE-040426-1612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Aprin; zgc:66331; zgc:153878
    Summary
    Predicted to be involved in DNA repair; mitotic sister chromatid cohesion; and negative regulation of DNA replication. Predicted to act upstream of or within cell division. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human PDS5A (PDS5 cohesin associated factor A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pds5a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (23323287..23370529, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22632559..22679820, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 14 Neighboring gene ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) Neighboring gene NEDD4 binding protein 2 Neighboring gene ras homolog family member H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Mönnich M, et al. Gene Expr Patterns, 2009 Dec. PMID 19723591
    2. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
    3. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    4. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66331, MGC153878

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sister chromatid cohesion protein PDS5 homolog A
    Names
    PDS5, regulator of cohesion maintenance, homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200992.3 → NP_957286.3  sister chromatid cohesion protein PDS5 homolog A

      Status: VALIDATED

      Source sequence(s)
      CR759875
      UniProtKB/Swiss-Prot
      A1L1F4
      UniProtKB/TrEMBL
      A0A8M2BI71, F1QDE7
      Related
      ENSDARP00000109877.2, ENSDART00000126785.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      23323287..23370529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170916.5 → XP_005170973.1  sister chromatid cohesion protein PDS5 homolog A isoform X2

      UniProtKB/Swiss-Prot
      A1L1F4
      UniProtKB/TrEMBL
      A0A8M2BI71, F1QDE7
      Conserved Domains (2) summary
      pfam06614
      Location:1221 → 1318
      Neuromodulin; Neuromodulin
      sd00044
      Location:279 → 309
      HEAT; HEAT repeat [structural motif]

    2. XM_068214592.1 → XP_068070693.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

      UniProtKB/Swiss-Prot
      A1L1F4

    3. XM_068214606.1 → XP_068070707.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

      UniProtKB/Swiss-Prot
      A1L1F4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394481.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      58757..105993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L1F4.1 GenPept UniProtKB/Swiss-Prot:A1L1F4

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