emc3 ER membrane protein complex subunit 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: emc3provided by ZNC
Official Full Name: ER membrane protein complex subunit 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2904
See related: Ensembl:ENSDARG00000020607 AllianceGenome:ZFIN:ZDB-GENE-040426-2904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pob; tmem111; zgc:63727; wu:fi32f05; wu:fj63h08
Summary: Predicted to contribute to membrane insertase activity. Acts upstream of or within photoreceptor cell maintenance and retina development in camera-type eye. Located in Golgi apparatus and trans-Golgi network transport vesicle. Is expressed in several structures, including brain; digestive system; eye; immature eye; and yolk syncytial layer. Orthologous to human EMC3 (ER membrane protein complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (42369999..42377311, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (42372463..42379775, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Not involved in phototransduction but rather plays an essential role in protein sorting and/or trafficking.
Title: The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells.

Submit: New GeneRIF Correction

General gene information

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Markers

fb36f05.x1 (e-PCR)
- UniSTS:190482

fb36f12.x1 (e-PCR)
- UniSTS:190486

fb37d04.x1 (e-PCR)
- UniSTS:190519

AW154780 (e-PCR)
- UniSTS:205899

fj63h08.x1 (e-PCR)
- UniSTS:188758

AW154346 (e-PCR)
- UniSTS:205913

fi32f05.x1 (e-PCR)
- UniSTS:197289

fb36f05 (e-PCR)
- UniSTS:187115

fb36f12 (e-PCR)
- UniSTS:187118

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ER membrane protein complex subunit 3

Names: partial optokinetic response b; protein pob; transmembrane protein 111

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.