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    elf1 E74-like ETS transcription factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 30396, updated on 2-Nov-2024

    Summary

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    Official Symbol
    elf1provided by ZNC
    Official Full Name
    E74-like ETS transcription factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-335
    See related
    Ensembl:ENSDARG00000020759 AllianceGenome:ZFIN:ZDB-GENE-980526-335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ef1; zef1; fb05d07; wu:fb05d07
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in endothelial cell; periderm; and telencephalon. Orthologous to several human genes including ELF1 (E74 like ETS transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See elf1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (40745833..40850377, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (40378579..40483114, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene protocadherin 19 Neighboring gene tenomodulin Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors. Mouriec K, et al. Biol Reprod, 2009 May. PMID 19129512
    2. D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. Ghiselli G, et al. BMC Dev Biol, 2005 Sep 12. PMID 16156897, Free PMC Article
    3. Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis. Liu F, et al. Circ Res, 2008 Nov 7. PMID 18832752
    4. ETS factors regulate Vegf-dependent arterial specification. Wythe JD, et al. Dev Cell, 2013 Jul 15. PMID 23830865, Free PMC Article
    5. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-1
    Names
    E74-like factor 1 (ets domain transcription factor)
    ETS-related factor1
    etID23096.14
    etID32924.14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131159.2 → NP_571234.2  ETS-related transcription factor Elf-1

      Status: VALIDATED

      Source sequence(s)
      BX510995
      UniProtKB/TrEMBL
      A0A8M6Z2K0, E7F1J0
      Related
      ENSDARP00000107670.2, ENSDART00000122369.4
      Conserved Domains (2) summary
      pfam00178
      Location:203 → 282
      Ets; Ets-domain
      pfam12310
      Location:2 → 107
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      40745833..40850377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213153.1 → XP_068069254.1  ETS-related transcription factor Elf-1 isoform X2

    2. XM_017358979.3 → XP_017214468.1  ETS-related transcription factor Elf-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2K0, E7F1J0
      Conserved Domains (2) summary
      pfam00178
      Location:203 → 282
      Ets; Ets-domain
      pfam12310
      Location:2 → 107
      Elf-1_N; Transcription factor protein N terminal

    3. XM_017358978.3 → XP_017214467.1  ETS-related transcription factor Elf-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2K0, E7F1J0
      Conserved Domains (2) summary
      pfam00178
      Location:203 → 282
      Ets; Ets-domain
      pfam12310
      Location:2 → 107
      Elf-1_N; Transcription factor protein N terminal

    4. XM_017358980.3 → XP_017214469.1  ETS-related transcription factor Elf-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z202

    5. XM_068213154.1 → XP_068069255.1  ETS-related transcription factor Elf-1 isoform X3

    6. XM_017358977.3 → XP_017214466.1  ETS-related transcription factor Elf-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2K0, E7F1J0
      Conserved Domains (2) summary
      pfam00178
      Location:203 → 282
      Ets; Ets-domain
      pfam12310
      Location:2 → 107
      Elf-1_N; Transcription factor protein N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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