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    TMA19 Tma19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853809, updated on 4-Aug-2024

    Summary

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    Gene symbol
    TMA19
    Gene description
    Tma19p
    Primary source
    FungiDB:YKL056C
    Locus tag
    YKL056C
    See related
    SGD:S000001539; AllianceGenome:SGD:S000001539; VEuPathDB:YKL056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MMI1
    Summary
    Predicted to enable calcium ion binding activity. Involved in cellular response to oxidative stress; cytoplasmic translation; and negative regulation of autophagy. Located in cytosol and mitochondrion. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TMA19 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (334412..334915, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA subunit gamma Neighboring gene Nup120p Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity. Rinnerthaler M, et al. PLoS One, 2013. PMID 24204967, Free PMC Article
    2. Mmi1, the Yeast Ortholog of Mammalian Translationally Controlled Tumor Protein (TCTP), Negatively Affects Rapamycin-Induced Autophagy in Post-Diauxic Growth Phase. Vojtova J, et al. Cells, 2020 Jan 7. PMID 31936125, Free PMC Article
    3. S. cerevisiae Strain Lacking Mitochondrial IF3 Shows Increased Levels of Tma19p during Adaptation to Respiratory Growth. Levitskii S, et al. Cells, 2019 Jun 26. PMID 31248014, Free PMC Article
    4. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Sanchez JC, et al. Electrophoresis, 1997 Jan. PMID 9059837
    5. Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae. Takahashi T, et al. J Toxicol Sci, 2010 Dec. PMID 21139346

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study demonstrates that in budding yeast Saccharomyces cerevisiae slow adaptation from glycolysis to respiration in the absence of mitochondrial translation initiation factor 3 (Aim23p) is accompanied by a gradual increase of cytochrome c oxidase activity and by increased levels of Tma19p protein, which protects mitochondria from oxidative stress.
      Title: S. cerevisiae Strain Lacking Mitochondrial IF3 Shows Increased Levels of Tma19p during Adaptation to Respiratory Growth.
    2. Mmi1p is one of the few proteins establishing a functional link between microtubules and mitochondria which may be needed for correct localization of mitochondria during cell division.
      Title: MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tma19p
    NP_012867.1
    • Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; homolog of human TPT1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      334412..334915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179622.1 → NP_012867.1  TPA: Tma19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012867.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXN1, P35691
      UniProtKB/TrEMBL
      A6ZZR0, B3LR35, C7GP18, C8ZCB6, G2WHX6, N1P7V2
      Conserved Domains (1) summary
      pfam00838
      Location:1 → 161
      TCTP; Translationally controlled tumor protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35691.1

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