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    LYS4 homoaconitate hydratase LYS4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851820, updated on 1-Aug-2024

    Summary

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    Gene symbol
    LYS4
    Gene description
    homoaconitate hydratase LYS4
    Primary source
    FungiDB:YDR234W
    Locus tag
    YDR234W
    See related
    SGD:S000002642; AllianceGenome:SGD:S000002642; VEuPathDB:YDR234W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LYS3
    Summary
    Predicted to enable homoaconitate hydratase activity. Involved in lysine biosynthetic process via aminoadipic acid. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LYS4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (931129..933210)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 5-aminolevulinate synthase Neighboring gene Rtn1p Neighboring gene mRNA splicing protein PRP42 Neighboring gene riboflavin kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A unique fungal lysine biosynthesis enzyme shares a common ancestor with tricarboxylic acid cycle and leucine biosynthetic enzymes found in diverse organisms. Irvin SD, et al. J Mol Evol, 1998 Apr. PMID 9541534
    2. The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine biosynthesis pathway. Weidner G, et al. Mol Gen Genet, 1997 Jul. PMID 9268014
    3. Homoaconitic acid accumulation by a lysine-requiring yeast mutant. Maragoudakis ME. J Bacteriol, 1967 Oct. PMID 6051343, Free PMC Article
    4. Homocitric acid accumulation by a lysine-requiring yeast mutant. Maragoudakis ME, et al. J Biol Chem, 1966 Feb 10. PMID 5908136
    5. Cloning and physical characterization of linked lysine genes (lys4, lys15) of Saccharomyces cerevisiae. Wang L, et al. Curr Genet, 1989 Jul. PMID 2507177

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homoaconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homoaconitate hydratase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homoaconitate hydratase LYS4
    NP_010520.3
    • Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      931129..933210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180542.3 → NP_010520.3  TPA: homoaconitate hydratase LYS4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010520.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSL5, P49367, Q66RF2, Q7LH77
      UniProtKB/TrEMBL
      B3LG54, C7GVB9, N1PAG0
      Conserved Domains (1) summary
      TIGR00139
      Location:20 → 693
      h_aconitase; homoaconitase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49367.1

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