IDH1 isocitrate dehydrogenase (NAD(+)) IDH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: IDH1
Gene description: isocitrate dehydrogenase (NAD(+)) IDH1
Primary source: FungiDB:YNL037C
Locus tag: YNL037C
See related: SGD:S000004982; AllianceGenome:SGD:S000004982; VEuPathDB:YNL037C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to isocitrate dehydrogenase (NAD+) activity. Involved in isocitrate metabolic process. Located in mitochondrial nucleoid. Part of mitochondrial isocitrate dehydrogenase complex (NAD+). Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to several human genes including IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IDH1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (557920..559002, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinetic analysis showed that ScIDH1 R148H and YlIDH R141H displayed 5.2-fold and 3.3-fold higher affinities, respectively, for alpha-KG than the HcIDH R132H mutant
Title: Single arginine mutation in two yeast isocitrate dehydrogenases: biochemical characterization and functional implication.
On the basis of a potential interaction between side chains of Cys-150 residues in IDH2 subunits in each tetramer of the enzyme, ligand binding assays of wild-type (IDH1/IDH2) and IDH1/IDH2(C150S) octameric enzymes were conducted.
Title: Basis for half-site ligand binding in yeast NAD(+)-specific isocitrate dehydrogenase.
analysis of allosteric motion in the IDH1 and IDH2 subunits of NAD+-specific isocitrate dehydrogenase
Title: Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase.
allosteric activation of IDH has an important physiological role during changes in environmental conditions
Title: Physiological consequences of loss of allosteric activation of yeast NAD+-specific isocitrate dehydrogenase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
contributes_to isocitrate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutamate biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of isocitrate dehydrogenase complex (NAD+)	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: isocitrate dehydrogenase (NAD(+)) IDH1

NP_014361.1

EC 1.1.1.41

Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

557920..559002 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182876.1 → NP_014361.1 TPA: isocitrate dehydrogenase (NAD(+)) IDH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014361.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1E2, P28834

UniProtKB/TrEMBL

A0A6A5Q932, A6ZS41, B3LNP9, B5VR01, C7GLW3, C8ZFW0, G2WM66, N1P4J9

Conserved Domains (1) summary

TIGR00175
Location:26 → 357

mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type