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    DSS4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856128, updated on 11-Sep-2024

    Summary

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    Official Symbol
    DSS4
    Primary source
    SGD:S000006221
    Locus tag
    YPR017C
    See related
    AllianceGenome:SGD:S000006221; FungiDB:YPR017C; VEuPathDB:YPR017C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables guanyl-nucleotide exchange factor activity and zinc ion binding activity. Involved in post-Golgi vesicle-mediated transport. Located in cytosol and membrane. Orthologous to human RABIF (RAB interacting factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (593486..593917, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene translation initiation factor 6 Neighboring gene Rlf2p Neighboring gene MCM DNA helicase complex subunit MCM4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cycle of SEC4 function in vesicular transport. Novick P, et al. Ciba Found Symp, 1993. PMID 8299422
    2. Distinct subclasses of small GTPases interact with guanine nucleotide exchange factors in a similar manner. Day GJ, et al. Mol Cell Biol, 1998 Dec. PMID 9819430, Free PMC Article
    3. Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins. Esters H, et al. J Mol Biol, 2001 Jun 29. PMID 11419942
    4. Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast. Collins RN, et al. J Biol Chem, 1997 Jul 18. PMID 9218467
    5. DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function. Moya M, et al. Nature, 1993 Feb 4. PMID 8429886

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-Golgi vesicle-mediated transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor DSS4
    NP_015342.1
    • Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      593486..593917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184114.1 → NP_015342.1  TPA: guanine nucleotide exchange factor DSS4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W427, P32601, Q12299, Q3S1N1
      UniProtKB/TrEMBL
      A6ZWR0, B3LL78, C7GQC1, C8ZJ42, G2WPJ5, N1NW81
      Conserved Domains (1) summary
      cd00246
      Location:2 → 136
      RabGEF; Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32601.2

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