CPEB2 cytoplasmic polyadenylation element binding protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CPEB2provided by HGNC
Official Full Name: cytoplasmic polyadenylation element binding protein 2provided by HGNC
Primary source: HGNC:HGNC:21745
See related: Ensembl:ENSG00000137449 MIM:610605; AllianceGenome:HGNC:21745
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CPEB-2; CPE-BP2; hCPEB-2
Summary: The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 12.0), skin (RPKM 7.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p15.32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (15002481..15070151)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (14984261..15051932)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (15004105..15071775)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration.
Title: A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration.
CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma.
Title: CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma.
CPEB2 enhances cell growth and angiogenesis by upregulating ARPC5 mRNA stability in multiple myeloma.
Title: CPEB2 enhances cell growth and angiogenesis by upregulating ARPC5 mRNA stability in multiple myeloma.
CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Title: CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer.
Title: The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer.
A positive feedback self-regulatory loop between miR-210 and HIF-1alpha mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsiadagger.
Title: A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia†.
Data demonstrated an increased occurrence of both SRSF3 and the CPEB2B isoform in triple negative breast cancer (TNBC), and identified a consensus binding motif for SRSF3 in the exon promoting the CPEB2B isoform. The study also suggests that the splicing event, which promotes the expression of CPEB2B, is driven by SRSF3 as well as linked to aggressive growth in metastatic TNBC.
Title: Serine/Arginine-Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2.
CPEB2, presumably the isoform A, plays a key role in suppressing tumorigenesis in mammary epithelial cells by repressing EMT, migration, invasion, proliferation and stem-like cells phenotype, via multiple targets, including a newly-identified translational target p53.
Title: Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells.
Our findings demonstrated the overexpression of miR-885-5p in liver metastasis and its roles in inducing CRC metastasis, potentiating development of miR-885-5p inhibitor to treat advanced CRC in the future.
Title: Identification of microRNA 885-5p as a novel regulator of tumor metastasis by targeting CPEB2 in colorectal cancer.
Long non-coding RNA TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis.
Title: TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-67263 (e-PCR)
- UniSTS:46348

SHGC-67966 (e-PCR)
- UniSTS:49177

MARC_12073-12074:1004623170:1 (e-PCR)
- UniSTS:267329

MARC_12073-12074:1007731941:3 (e-PCR)
- UniSTS:267329

SHGC-67785 (e-PCR)
- UniSTS:30053

G59401 (e-PCR)
- UniSTS:136566

G34337 (e-PCR)
- UniSTS:33411

WI-14109 (e-PCR)
- UniSTS:902

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal large subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal small subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translational elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 2

Names: CPE-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177381.2 → NP_001170852.1 cytoplasmic polyadenylation element-binding protein 2 isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (C) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant D. The resulting isoform (C) differs at an internal region, compared to isoform D.

Source sequence(s)

AC098829, AC105289, BC103939

Consensus CDS

CCDS56326.1

UniProtKB/Swiss-Prot

Q7Z5Q1

Related

ENSP00000414270.2, ENST00000442003.6

Conserved Domains (4) summary

COG0724
Location:737 → 912

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:750 → 841

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:858 → 938

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:933 → 994

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001177382.2 → NP_001170853.1 cytoplasmic polyadenylation element-binding protein 2 isoform D

Status: REVIEWED

Description

Transcript Variant: This variant (D) represents the longest transcript and encodes the longest isoform (D).

Source sequence(s)

AC098829, AC105289, BC103942

Consensus CDS

CCDS56325.1

UniProtKB/Swiss-Prot

Q7Z5Q1

Related

ENSP00000443985.1, ENST00000538197.7

Conserved Domains (4) summary

COG0724
Location:764 → 939

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:777 → 868

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:885 → 965

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:960 → 1021

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001177383.2 → NP_001170854.1 cytoplasmic polyadenylation element-binding protein 2 isoform E

Status: REVIEWED

Description

Transcript Variant: This variant (E) lacks an alternate in-frame exon in the central coding region, compared to variant D. The resulting isoform (E) lacks an internal segment, compared to isoform D.

Source sequence(s)

AC098829, AC105289, BC103941

Consensus CDS

CCDS93479.1

UniProtKB/TrEMBL

A0A5K1VW71

Related

ENSP00000371832.4, ENST00000382395.8

Conserved Domains (4) summary

COG0724
Location:734 → 909

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:747 → 838

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:855 → 935

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:930 → 991

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001177384.2 → NP_001170855.1 cytoplasmic polyadenylation element-binding protein 2 isoform F

Status: REVIEWED

Description

Transcript Variant: This variant (F) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the central coding region, compared to variant D. The resulting isoform (F) differs at two internal regions, compared to isoform D.

Source sequence(s)

AC098829, AC105289, BC105925

Consensus CDS

CCDS93480.1

UniProtKB/TrEMBL

A0A5K1VW79

Related

ENSP00000371838.4, ENST00000382401.8

Conserved Domains (4) summary

COG0724
Location:729 → 904

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:742 → 833

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:850 → 930

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:925 → 986

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_182485.3 → NP_872291.2 cytoplasmic polyadenylation element-binding protein 2 isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (B) lacks two alternate in-frame exons in the central coding region, compared to variant D. The resulting isoform (B) lacks two internal segments, compared to isoform D.

Source sequence(s)

AC098829, AC105289, AY247744

UniProtKB/TrEMBL

A0A5K1VW93

Related

ENSP00000424084.2, ENST00000507071.6

Conserved Domains (4) summary

COG0724
Location:756 → 931

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:769 → 860

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:877 → 957

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:952 → 1013

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_182646.3 → NP_872587.2 cytoplasmic polyadenylation element-binding protein 2 isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (A) lacks an alternate in-frame exon in the central coding region, compared to variant D. The resulting isoform (A) lacks an internal segment, compared to isoform D.

Source sequence(s)

AC098829, AC105289, AY255519

UniProtKB/TrEMBL

A0A5K1VW61

Related

ENSP00000334058.4, ENST00000345451.8

Conserved Domains (4) summary

COG0724
Location:726 → 901

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:739 → 830

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:847 → 927

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:922 → 983

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

15002481..15070151

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005248135.4 → XP_005248192.2 cytoplasmic polyadenylation element-binding protein 2 isoform X1

Conserved Domains (4) summary

COG0724
Location:767 → 942

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:780 → 871

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:888 → 968

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:963 → 1024

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
XM_011513777.4 → XP_011512079.1 cytoplasmic polyadenylation element-binding protein 2 isoform X2

Conserved Domains (4) summary

COG0724
Location:759 → 934

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:772 → 863

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:880 → 960

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:955 → 1016

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
XM_011513778.4 → XP_011512080.1 cytoplasmic polyadenylation element-binding protein 2 isoform X3
XM_011513779.3 → XP_011512081.1 cytoplasmic polyadenylation element-binding protein 2 isoform X4
XM_017007734.3 → XP_016863223.1 cytoplasmic polyadenylation element-binding protein 2 isoform X5

Conserved Domains (3) summary

pfam16366
Location:389 → 450

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:206 → 297

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:314 → 394

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_017007733.2 → XP_016863222.1 cytoplasmic polyadenylation element-binding protein 2 isoform X5

Conserved Domains (3) summary

pfam16366
Location:389 → 450

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:206 → 297

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:314 → 394

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_047449609.1 → XP_047305565.1 cytoplasmic polyadenylation element-binding protein 2 isoform X6

Reference GRCh38.p14 PATCHES

Genomic

NW_013171799.1 Reference GRCh38.p14 PATCHES

Range

74375..89176

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

14984261..15051932

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348925.1 → XP_054204900.1 cytoplasmic polyadenylation element-binding protein 2 isoform X1
XM_054348926.1 → XP_054204901.1 cytoplasmic polyadenylation element-binding protein 2 isoform X2
XM_054348927.1 → XP_054204902.1 cytoplasmic polyadenylation element-binding protein 2 isoform X3
XM_054348928.1 → XP_054204903.1 cytoplasmic polyadenylation element-binding protein 2 isoform X4
XM_054348929.1 → XP_054204904.1 cytoplasmic polyadenylation element-binding protein 2 isoform X5
XM_054348930.1 → XP_054204905.1 cytoplasmic polyadenylation element-binding protein 2 isoform X5
XM_054348931.1 → XP_054204906.1 cytoplasmic polyadenylation element-binding protein 2 isoform X6